Keratinocytes in epidermal immune responses

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

2000 • 1,219 citations

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

2000 • 926 citations

Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with <scp>l</scp>-Lysine

2001 • 736 citations

Neuroendocrinology of the Skin1

2000 • 678 citations

Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

2001 • 648 citations

Large and Sustained Induction of Chemokines during Impaired Wound Healing in the Genetically Diabetic Mouse: Prolonged Persistence of Neutrophils and Macrophages during the Late Phase of Repair

2000 • 553 citations

Interleukin 20

2001 • 542 citations

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

2000 • 533 citations

Keratins and the Keratinocyte Activation Cycle

2001 • 520 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

Delayed Wound Healing in CXCR2 Knockout Mice

2000 • 401 citations

Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors

2000 • 377 citations

Papillomavirus Type 16 Oncogenes Downregulate Expression of Interferon-Responsive Genes and Upregulate Proliferation-Associated and NF-κB-Responsive Genes in Cervical Keratinocytes

2001 • 374 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

2000 • 357 citations

A Th2 Chemokine, TARC, Produced by Keratinocytes May Recruit CLA+CCR4+ Lymphocytes into Lesional Atopic Dermatitis Skin

2000 • 342 citations

Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)

2000 • 327 citations

Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells

2000 • 322 citations

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

2000 • 303 citations

Interleukin-17 is Produced by Both Th1 and Th2 Lymphocytes, and Modulates Interferon-γ- and Interleukin-4-Induced Activation of Human Keratinocytes

2000 • 289 citations

Microarray Analysis Identifies Interferon-Inducible Genes and Stat-1 as Major Transcriptional Targets of Human Papillomavirus Type 31

2000 • 285 citations

Discovery of new human β-defensins using a genomics-based approach

2001 • 249 citations

Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts

2000 • 229 citations

Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells

2000 • 218 citations

Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris

2001 • 212 citations

Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?

2000 • 209 citations

Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis

2001 • 188 citations

Interleukin (IL)‐18 induces Langerhans cell migration by a tumour necrosis factor‐α‐ and IL‐1β‐dependent mechanism

2001 • 180 citations

Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

2001 • 178 citations

A role for NF-κB–dependent gene transactivation in sunburn

2000 • 161 citations

Disparate Cytotoxic Activity of Nickel-Specific CD8+ and CD4+ T Cell Subsets Against Keratinocytes

2000 • 148 citations

Treatment of psoriatic arthritis with antitumour necrosis factor-α antibody clears skin lesions of psoriasis resistant to treatment with methotrexate

2001 • 146 citations

CD44 as a receptor for colonization of the pharynx by group A Streptococcus

2000 • 145 citations

Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18

2000 • 132 citations

Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo

2001 • 130 citations

Response of Psoriasis to Interleukin-10 is Associated with Suppression of Cutaneous Type 1 Inflammation, Downregulation of the Epidermal Interleukin-8/CXCR2 Pathway and Normalization of Keratinocyte Maturation

2001 • 125 citations

Neurotrophin-4 Production by Human Epidermal Keratinocytes: Increased Expression in Atopic Dermatitis

2000 • 115 citations

Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

2001 • 102 citations

A Role for Parasite-Induced PGE2 in IL-10-Mediated Host Immunoregulation by Skin Stage Schistosomula ofSchistosoma mansoni

2000 • 98 citations

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation

2001 • 95 citations

α-Melanocyte-stimulating Hormone Reduces Impact of Proinflammatory Cytokine and Peroxide-generated Oxidative Stress on Keratinocyte and Melanoma Cell Lines

2000 • 82 citations

IFN-γ Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages

2000 • 79 citations

The Role of α‐MSH as a Modulator of Cutaneous Inflammation

2000 • 78 citations

Protein Kinase C-α Coordinately Regulates Cytosolic Phospholipase A₂Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes

2001 • 58 citations

In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin

2001 • 57 citations

Reversal of ultraviolet radiation‐induced immune suppression by recombinant interleukin‐12: suppression of cytokine production

2000 • 57 citations

The treatment of psoriasis with IL-10: rationale and review of the first clinical trials

2000 • 51 citations

Allergens and Irritants Transcriptionally Upregulate CD80 Gene Expression in Human Keratinocytes

2000 • 50 citations

Transforming growth factor-beta(1), -beta(2), -beta(3), basic fibroblast growth factor and vascular endothelial growth factor expression in keratinocytes of burn scars.

2000 • 48 citations

Human keratinocytes are major producers of IL-18: predominant expression of the unprocessed form.

2000 • 45 citations

Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation

2001 • 43 citations

Correlation between Pretreatment Levels of Interferon Response Genes and Clinical Responses to an Immune Response Modifier (Imiquimod) in Genital Warts

2000 • 41 citations

Regulation of interleukin-18 (IL-18) expression in keratinocytes (HaCaT): implications for early wound healing.

2000 • 41 citations

Vasoactive Intestinal Peptide Regulates its Receptor Expression and Functions of Human Keratinocytes via Type I Vasoactive Intestinal Peptide Receptors

2001 • 41 citations

The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes

2000 • 36 citations

Activation of the IL-10 Gene Promoter Following Photodynamic Therapy of Murine Keratinocytes¶

2001 • 32 citations

Interferon-Gamma-Induced RANTES Production by Human Keratinocytes Is Enhanced by IL-1β, TNF-α, IL-4 and IL-13 and Is Inhibited by Dexamethasone and Tacrolimus

2001 • 30 citations

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