Molecular Basis of Allergic Diseases

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

Bronchoscopic Evaluation of Severe Asthma

1997 • 775 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children

1994 • 762 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Effects of Reducing or Discontinuing Inhaled Budesonide in Patients with Mild Asthma

1994 • 755 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Particulate Air Pollution and Hospital Emergency Room Visits for Asthma in Seattle

1993 • 656 citations

Eosinophil-associated TGF- β₁mRNA Expression and Airways Fibrosis in Bronchial Asthma

1997 • 639 citations

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1995 • 636 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber

1982 • 627 citations

The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma

1989 • 611 citations

Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?

1993 • 588 citations

Asthma and inflammation.

2012 • 569 citations

Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

1995 • 557 citations

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.

1993 • 525 citations

Genetics of Asthma and Hay Fever in Australian Twins

1990 • 510 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

1993 • 457 citations

Late cutaneous allergic responses in isolated IgE-dependent reactions

1973 • 454 citations

IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells.

1995 • 424 citations

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1997 • 413 citations

Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

1995 • 407 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

1992 • 388 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma.

1995 • 355 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Allergen exposure induces the activation of allergen‐specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders

1993 • 348 citations

The occurrence of atopic dermatitis in North Europe: An international questionnaire study

1996 • 346 citations

CONTROLLED TRIAL OF HYPOSENSITISATION TO DERMATOPHAGOIDES PTERONYSSINUS IN CHILDREN WITH ASTHMA

1978 • 344 citations

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

1991 • 333 citations

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

1995 • 316 citations

Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects

1995 • 298 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE.

1990 • 293 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

NUTRITIONAL MUSCULAR DYSTROPHY AND HUMAN MYOCARDIAL INFARCTION

1973 • 280 citations

Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

1992 • 277 citations

Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy.

1997 • 275 citations

Eosinophil apoptosis and the resolution of airway inflammation in asthma.

1996 • 267 citations

Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo.

1991 • 256 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

The role of adhesion molecules in human eosinophil and basophil recruitment

1994 • 243 citations

Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.

1991 • 233 citations

Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.

1995 • 224 citations

IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells.

1992 • 223 citations

Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

1994 • 219 citations

Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro

1995 • 197 citations

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

1994 • 192 citations

Expression of endothelial-leukocyte adhesion molecule-1 in elicited late phase allergic reactions.

1991 • 185 citations

Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.

1997 • 183 citations

The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.

1997 • 180 citations

Glucocorticoid Resistance in Chronic Asthma: Peripheral Blood T Lymphocyte Activation and Comparison of the T Lymphocyte Inhibitory Effects of Glucocorticoids and Cyclosporin A

1991 • 179 citations

Enhanced IL-4 Production and IL-4 Receptor Expression in Atopic Dermatitis and Their Modulation by Interferon-Gamma

1992 • 151 citations

Granulocyte macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis.

1995 • 139 citations

Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics.

1997 • 138 citations

An Update on Human Th1 and Th2 Cells

1997 • 136 citations

Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis.

1993 • 133 citations

Glucocorticoid receptors and actions.

1990 • 132 citations

Chemokines in allergic inflammation☆, ☆☆, ★

1997 • 122 citations

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects

1992 • 119 citations

Steroid-resistant asthma: Immunologic and pharmacologic features

1992 • 108 citations

Cytokine regulation of eosinophil function

1992 • 101 citations

Asthma genetics: waiting to exhale

1997 • 101 citations

Enhanced Expression of B7.2 (CD86) in Patients with Atopic Dermatitis: A Potential Role in the Modulation of IgE Synthesis

1998 • 84 citations

Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma

1998 • 76 citations

Role of IgE in atopic dermatitis

1993 • 76 citations

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

1992 • 72 citations

Interleukin 2 synthesis in the presence of steroids: a model of steroid resistance.

1987 • 58 citations

Allergic Models and Cytokines

1994 • 34 citations

Novel Fundamental Approaches to Intervening in IgE-Mediated Allergic Diseases

1994 • 33 citations

Altered glucocorticoid receptor binding in atopic dermatitis

1995 • 33 citations

Total serum IgE levels and chromosome 5q

1995 • 33 citations

Gold sodium thiomalate selectivity inhibits interleukin-5–mediated eosinophil survival

1995 • 25 citations

Adhesion Molecules in Allergic Disease

2020 • 22 citations

Adhesion Molecules in Allergic Disease

1998 • 14 citations