Interleukin-1 and Cutaneous Inflammation: A Crucial Link Between Innate and Acquired Immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Interleukin-1

1984 • 1,625 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor

1994 • 1,323 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Signaling in Plant-Microbe Interactions

2013 • 764 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

1998 • 634 citations

Limb and Skin Abnormalities in Mice Lacking IKKα

1999 • 609 citations

RISK OF CANCER IN RENAL-TRANSPLANT RECIPIENTS

1973 • 607 citations

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

1998 • 604 citations

Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

1997 • 582 citations

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

1998 • 573 citations

A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites.

1990 • 512 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

TLR6: A novel member of an expanding Toll-like receptor family

1999 • 437 citations

Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells

1997 • 437 citations

Epidermal cell (keratinocyte)-derived thymocyte-activating factor (ETAF).

1981 • 420 citations

Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells.

1993 • 393 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Overview of interleukin-18: more than an interferon-γ inducing factor

1998 • 371 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

1997 • 330 citations

Epidermal Cell Production of Thymocyte Activating Factor (ETAF)

1982 • 319 citations

Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein

1992 • 315 citations

Regulated nuclear import of Rel proteins in the Drosophila immune response

1998 • 314 citations

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

1997 • 311 citations

Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.

1990 • 303 citations

Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

1996 • 302 citations

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.

1994 • 295 citations

Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase

1999 • 283 citations

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1997 • 277 citations

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

1990 • 270 citations

Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

1999 • 267 citations

Phosphatidylinositol 3-Kinase in Interleukin 1 Signaling

1997 • 231 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.

1995 • 224 citations

Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans

1998 • 222 citations

Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1

1993 • 214 citations

Interleukin 1 is present in normal human epidermis.

1986 • 214 citations

T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family

1996 • 212 citations

Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

1991 • 209 citations

Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.

1995 • 194 citations

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

1994 • 192 citations

Interleukin-1

1998 • 181 citations

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

1999 • 178 citations

The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells.

1996 • 178 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Incidence of Skin Carcinoma After Renal Transplantation

1977 • 173 citations

IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor

1998 • 169 citations

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice

1999 • 164 citations

The Type II IL-1 Receptor Interacts with the IL-1 Receptor Accessory Protein: A Novel Mechanism of Regulation of IL-1 Responsiveness

1998 • 164 citations

Regulation of E-Cadherin-Mediated Adhesion in Langerhans Cell-Like Dendritic Cells by Inflammatory Mediators That Mobilize Langerhans Cells In Vivo

1998 • 164 citations

The Interleukin-1 Axis and Cutaneous Inflammation

1995 • 163 citations

Interleukin-1 Receptor antagonist Production by Human Keratinocytes

1992 • 152 citations

Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 • 152 citations

A mechanism for the inhibition of fever by a virus.

1996 • 143 citations

Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells.

1994 • 134 citations

Expression of ST2, an Interleukin-1 Receptor Homologue, Is Induced by Proinflammatory Stimuli

1997 • 125 citations

Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist.

1997 • 122 citations

Cutaneous lymphocyte antigen‐positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis

1996 • 122 citations

The N-terminal propiece of interleukin 1α is a transforming nuclear oncoprotein

1997 • 112 citations

The Immunopemthogenesis of Cutaneous T-cell Lymphoma

1995 • 108 citations

Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.

1993 • 108 citations

Effect of In Vivo Interleukin-1 on Adhesion Molecule Expression in Normal Human Skin

1992 • 103 citations

Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation

1997 • 96 citations

Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease.

1996 • 89 citations

Regulatory Role of Ceramide in Interleukin (IL)-1β-induced E-selectin Expression in Human Umbilical Vein Endothelial Cells

1996 • 77 citations

Activation of Acid Sphingomyelinase by Interleukin-1 (IL-1) Requires the IL-1 Receptor Accessory Protein

1997 • 77 citations

Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I

1998 • 75 citations

Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis.

1994 • 62 citations

Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor.

1999 • 56 citations

The IL1 receptor accessory protein is responsible for the recruitment of the interleukin‐1 receptor associated kinase to the IL1/IL1 receptor I complex

1997 • 55 citations

Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.

1995 • 49 citations

Selectins, T-cell rolling and inflammation

1997 • 49 citations

Human Immunodeficiency Virus and the Skin: Selected Controversies

1995 • 40 citations

Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.

1996 • 39 citations

DISTINCT ROLES FOR p42/p44 AND p38 MITOGEN-ACTIVATED PROTEIN KINASES IN THE INDUCTION OF IL-2 BY IL-1

1999 • 38 citations

Antiproliferative Effect of IL-1 Is Mediated by p38 Mitogen-Activated Protein Kinase in Human Melanoma Cell A375

1999 • 26 citations