Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

Keratinocytes as initiators of inflammation

1991 • 756 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

1993 • 615 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Textbook of Contact Dermatitis

1995 • 493 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

The skin immune system: progress in cutaneous biology

1993 • 387 citations

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

1995 • 365 citations

Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions.

1991 • 341 citations

Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.

1990 • 315 citations

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

1995 • 243 citations

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation.

1993 • 241 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

Epidermal Langerhans Cells

2024 • 172 citations

Regulation of contact hypersensitivity by interleukin 10.

1994 • 168 citations

In Vivo Effects of Interleukin-10 on Contact Hypersensitivity and Delayed-Type Hypersensitivity Reactions

1994 • 158 citations

alpha-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice.

1996 • 153 citations

Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity.

1995 • 152 citations

Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis.

1990 • 147 citations

Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice.

1995 • 146 citations

Effect of glucocorticosteroids on epidermal Langerhans cells.

1982 • 146 citations

The immunologic properties of epidermal Langerhans cells as a part of the dendritic cell system

1992 • 140 citations

Common Pathogenetic Pathways in Allergic and Irritant Contact Dermatitis

1992 • 137 citations

Nickel Chloride and Cobalt Chloride, Two Common Contact Sensitizers, Directly Induce Expression of Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Endothelial Leukocyte Adhesion Molecule (ELAM-1) by Endothelial Cells

1993 • 134 citations

Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide.

1995 • 134 citations

In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse.

1986 • 130 citations

Epidermal Growth Factors and Cytokines

1993 • 125 citations

Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

1993 • 124 citations

T Cell Recognition of Haptens, a Molecular View

1994 • 122 citations

Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1.

1993 • 120 citations

Stimulation of Langerhans Cell Migration by Tumor Necrosis Factor α (TNF-α)

1992 • 114 citations

Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.

1991 • 113 citations

`Irritants' Increase the Response to an Allergen in Allergic Contact Dermatitis

1991 • 111 citations

Immunopathological and ultrastructural findings in human allergic and irritant contact dermatitis

1986 • 110 citations

Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance.

1996 • 107 citations

Psoriatic Epidermal Cells Demonstrate Increased Numbers and Function of Non-Langerhans Antigen-presenting Cells

1989 • 105 citations

Neutrophils, Differentiated Macrophages, and Monocyte/Macrophage Antigen Presenting Cells Infiltrate Murine Epidermis After UV Injury

1993 • 97 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 94 citations

An unexpected increase in circulating IFN-gamma by cyclosporin A in atopic patients: a discrepancy between in vitro and in vivo events.

1994 • 91 citations

Effects of physicochemical agents on murine epidermal Langerhans cells and Thy-1-positive dendritic epidermal cells.

1986 • 90 citations

Interleukin-1 Receptor Antagonist Suppresses Contact Hypersensitivity

1995 • 83 citations

Contact dermatitis with negative patch tests: the additive effect of allergens in combination

1990 • 77 citations

Hyporesponsiveness in Contact Hypersensitivity and Irritant Contact Dermatitis in CD4 Gene Targeted Mouse

1996 • 74 citations

Interleukin-4 is a critical cytokine in contact sensitivity.

1995 • 71 citations

Recent Investigations of Mechanisms of Chemically Induced Skin Irritation in Laboratory Mice.

1987 • 62 citations

Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.

1993 • 58 citations

Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression.

1995 • 55 citations

Characterization of epidermal cytokine profiles in sensitization and elicitation phases of allergic contact dermatitis as well as irritant contact dermatitis in mouse skin.

1994 • 53 citations

Delayed-type hypersensitivity initiation by early-acting cells that are antigen mismatched or MHC incompatible with late-acting, delayed-type hypersensitivity effector T cells.

1991 • 53 citations

Direct Effects of Glucocorticosteroids on Epidermal Langerhans Cells

1989 • 53 citations

Infiltration of Both T Cells and Neutrophils in the Skin Is Accompanied by the Expression of Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1): An Immunohistochemical and Ultrastructural Study

1992 • 46 citations

Chemokine expression in trinitrochlorobenzene-mediated contact hypersensitivity

1994 • 44 citations

Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen.

1994 • 44 citations

Expression of the Calcium-Binding Proteins MRP8 and MRP14 by Early Infiltrating Cells in Experimental Contact Dermatitis

1992 • 42 citations

Expression and function of B7‐1 and B7‐2 in hapten‐induced contact sensitivity

1996 • 41 citations

The Role of Antigen-Presenting Cells in the Regulation of Delayed-Type Hypersensitivity

1993 • 40 citations

Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice.

1994 • 39 citations

Induction of inflammatory cytokines in murine keratinocytes upon in vivo stimulation with contact sensitizers and tolerizing analogues

1992 • 37 citations

Low doses of low molecular weight heparin in vivo inhibits the elicitation of contact hypersensitivity.

1994 • 34 citations

Expression of Intercellular Adhesion Molecule-1 in Murine Allergic Contact Dermatitis

1990 • 34 citations

Enhancement of the Elicitation Phase of the Murine Contact Hypersensitivity Response by Prior Exposure to Local Ultraviolet Radiation

1986 • 33 citations

The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. I. Spleen dendritic cells.

1992 • 24 citations

Lymphocyte function-associated antigen-1 is required for maximum elicitation of allergic contact dermatitis

1994 • 20 citations

Contact dermatitis: clinical review of 800 patients tested using the standard European series.

1995 • 20 citations

DNFB Contact Sensitivity (CS) In BALB/c and C3H/He Mice: Requirement for Early-Occurring, Early-Acting, Antigen-Specific, CS-Initiating Cells with an Unusual Phenotype (Thy-1+, CD5+, CD3-, CD4-, CD8-, sIg-, B220+, MHC Class II-, CD23+, IL-2R-, IL-3R+, Mel-14-, Pgp-1+, J11d+, MAC-1+, LFA-1+, and FcγRII+

1994 • 19 citations

Elicitation of Nickel Sulfate (NiSO4)-Specific Delayed-Type Hypersensitivity Requires Early-Occurring and Early-Acting, NiSO4-Specific DTH-Initiating Cells with an Unusual Mixed Phenotype for an Antigen-Specific Cell

1995 • 17 citations

Allergic contact dermatitis in HIV‐positive patients

1994 • 13 citations

Paradoxical coexistence of contact dermatitis and anergy in a man with AIDS

1995 • 12 citations

The contact allergens nickel chloride and cobalt chloride directly induce expression of endothelial adhesion molecules.

1993 • 10 citations