Increased axon growth through astrocyte cell lines transfected with urokinase.

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Injury-Induced Proteoglycans Inhibit the Potential for Laminin-Mediated Axon Growth on Astrocytic Scars

1995 • 487 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Prevention of metastasis by inhibition of the urokinase receptor.

1993 • 387 citations

The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair.

1988 • 362 citations

Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro.

1994 • 306 citations

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

1986 • 297 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue.

1994 • 255 citations

Putative Inhibitory Extracellular Matrix Molecules at the Dorsal Root Entry Zone of the Spinal Cord during Development and after Root and Sciatic Nerve Lesions

1993 • 252 citations

Thalamocortical axons extend along a chondroitin sulfate proteoglycan- enriched pathway coincident with the neocortical subplate and distinct from the efferent path

1994 • 244 citations

The Role of Plasmhogen Activators in the Regulation of Connective Tissue Metalloproteinasesa

1992 • 243 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells.

1990 • 205 citations

Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth

1989 • 204 citations

An inhibitor of neurite outgrowth produced by astrocytes

1994 • 200 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

The growth of axons in three-dimensional astrocyte cultures

1989 • 173 citations

The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion

1992 • 165 citations

Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo.

1994 • 158 citations

Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody.

1993 • 157 citations

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.

1991 • 156 citations

Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

1992 • 151 citations

Production of plasminogen activator by migrating cephalic neural crest cells.

1985 • 149 citations

Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors

1995 • 147 citations

Molecular motors in the nervous system

1991 • 141 citations

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1994 • 139 citations

The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth

1992 • 136 citations

Regenerating axons form nerve terminals at astrocytes

1985 • 124 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Characterization of a Neurite Outgrowth Inhibitor Expressed After CNS Injury

1993 • 118 citations

Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.

1995 • 116 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes

1991 • 110 citations

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor.

1993 • 108 citations

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor

1995 • 101 citations

The Metalloproteinase Stromelysin-1 (Transin) Mediates PC12 Cell Growth Cone Invasiveness through Basal Laminae

1995 • 87 citations

Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors.

1993 • 86 citations

Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human brain tumors.

1994 • 86 citations

Functional Involvement of Sciatic Nerve‐derived Versicanand Decorin‐like Molecules and other Chondroitin Sulphate Proteoglycans in ECM‐mediated Cell Adhesion and Neurite Outgrowth

1995 • 80 citations

PC12 Cells Overexpressing Tissue Plasminogen Activator Regenerate Neurites to a Greater Extent and Migrate Faster than Control Cells in Complex Extracellular Matrix

1995 • 80 citations

Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I

1987 • 80 citations

Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s)

1992 • 77 citations

An analysis of astrocytic cell lines with different abilities to promote axon growth

1995 • 71 citations

Regeneration of axons in the optic nerve of the adult Browman-Wyse (BW) mutant rat

1992 • 63 citations

Developmental transition in plasticity properties of differentiating astrocytes: Age‐related biochemical profile of plasminogen activators in astroglial cultures

1990 • 63 citations

α₂‐Macroglobulin Synthesis in an Astrocyte Subpopulation

1987 • 62 citations

Neurite Penetration into Collagen Gels Requires Ca<sup>2+</sup>-Dependent Metalloproteinase Activity

1989 • 61 citations

Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

1988 • 58 citations

Induction of Urokinase‐Type Plasminogen Activator in Rat Facial Nucleus by Axotomy of the Facial Nerve

1996 • 55 citations

Neurite outgrowth inhibitors associated with glial cells and glial cell lines

1993 • 54 citations

Cellular Biology of Cartilage Degradation

1995 • 49 citations

Induction of tissue‐type plasminogen activator and 72‐kDa type‐IV collagenase by ionizing radiation in rat astrocytes

1994 • 43 citations

Plasminogen Activators and Plasminogen Activator Inhibitors in Neural Developmenta

1992 • 42 citations

The effects of protease inhibitors on axon growth through astrocytes

1990 • 39 citations

A plasminogen activator is induced during goldfish optic nerve regeneration.

1990 • 37 citations

Differential regulation of astrocyte plasminogen activators by insulin-like growth factor-I and epidermal growth factor.

1994 • 35 citations

Enhanced release of plasminogen activator inhibitor(s) but not of plasminogen activators by cultured rat glial cells treated with interleukin‐1

1990 • 33 citations

Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells.

1994 • 32 citations

Evidence of a non-conventional role for the urokinase tripartite complex (uPAR/uPA/PAI-1) in myogenic cell fusion

1997 • 32 citations

Localization of the ceavage sites on fibronectin following digestion by urokinase

1992 • 29 citations

Modulation of plasminogen activator and plasminogen activator inhibitor expression in the human U373 glioblastoma/astrocytoma cell line by inflammatory mediators

1992 • 25 citations

Substrate specificity of tissue-type and urokinase-type plasminogen activators

1991 • 24 citations

Regrowth of PNS axons through grafts of the optic nerve of the Browman-Wyse (BW) mutant rat

1992 • 24 citations

Astrocytes Synthesize and Secrete α2-Macroglobulin: Differences Between the Regulation of α2-Macroglobulin Synthesis in Rat Liver and Brain

1988 • 21 citations

Modulation of the malignant phenotype with the urokinase-type plasminogen activator and the type I plasminogen activator inhibitor

1990 • 13 citations

Control of exogenous proteinases and their inhibitors at the macrophage cell surface

1989 • 5 citations