Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

The epidemiology of multiple sclerosis

2016 • 505 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

1985 • 463 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Measles Encephalomyelitis — Clinical and Immunologic Studies

1984 • 404 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

1994 • 311 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease.

1994 • 275 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Multiple sclerosis in the faroe islands: I. Clinical and epidemiological features

1979 • 257 citations

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

1989 • 239 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

1994 • 185 citations

Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.

1994 • 179 citations

Activation of latent Epstein–Barr virus by antibody to human IgM

1978 • 169 citations

T-cell recognition of myelin basic protein

1991 • 134 citations

Triggering and exacerbation of autoimmune arthritis by the mycoplasma arthritidis superantigen mam

1993 • 123 citations

THE GENETICS OF SUSCEPTIBILITY TO MULTIPLE SCLEROSIS1

1982 • 112 citations

Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding.

1991 • 108 citations

PATHOGENESIS OF INFECTIOUS MONONUCLEOSIS

1977 • 102 citations

Pathogenesis of herpes simplex labialis: experimental induction of lesions with UV light

1985 • 92 citations

Postinfectious Autoimmunity: Two Distinct Phases of Coxsackievirus B3‐Induced Myocarditis^a

1986 • 92 citations

Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells.

1991 • 69 citations

Induction of Epstein-Barr virus-associated DNA polymerase by 12-O-tetradecanoylphorbol-13-acetate. Purification and characterization.

1980 • 68 citations

Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus

1989 • 39 citations

Epidemiology of Multiple Sclerosis

1984 • 35 citations

COXSACKIE B VIRUS ANTIBODY RESPONSES IN JUVENILE‐ONSET DIABETES MELLITUS

1980 • 25 citations

Cells producing antibody to measles and herpes simplex virus in cerebrospinal fluid and blood of patients with multiple sclerosis and controls.

1989 • 20 citations

Recognition of the influenza hemagglutinin by class II MHC-restricted T lymphocytes and antibodies. I. Site definition and implications for antigen presentation and T lymphocyte recognition.

1991 • 15 citations

Occurrence of MRI Anormalities in Patients with Isolated Optic Neuritis

1990 • 8 citations