Animal models

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1983 • 295 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo.

1984 • 257 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

S-100 proteins

1986 • 220 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

Thymic selection: a matter of life and death

1992 • 184 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

RETINAL VENOUS SHEATHING IN OPTIC NEURITIS

1987 • 163 citations

T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes

1989 • 162 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

T-cell recognition of myelin basic protein

1991 • 134 citations

A STUDY OF THE CHEMICAL NATURE OF COMPONENTS OF BOVINE WHITE MATTER EFFECTIVE IN PRODUCING ALLERGIC ENCEPHALOMYELITIS IN THE RABBIT

1954 • 122 citations

Cell adhesion molecules of the immunoglobulin supergene family as tissue‐specific autoantigens: induction of experimental allergic neuritis (EAN) by PO protein‐specific T cell lines

1992 • 113 citations

Normal rat serum cytotoxicity against syngeneic oligodendrocytes

1989 • 102 citations

Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat

1988 • 95 citations

Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor V beta expression predominates in spinal cord infiltrating T cells.

1992 • 94 citations

Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis.

1993 • 86 citations

Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease

1993 • 82 citations

The major histocompatibility complex influences myelin basic protein 63‐88‐induced T cell cytokine profile and experimental autoimmune encephalomyelitis

1993 • 71 citations

Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis.

1993 • 68 citations

Regulatory circuits in autoimmunity: recruitment of counter‐regulatory CD8⁺ T cells by encephalitogenic CD4⁺ T line cells

1988 • 64 citations

T-Cell Autoimmunity in the Central Nervous System

1993 • 62 citations

Preferential distribution of Vβ 8.2‐positive T cells in the central nervous system of rats with myelin basic protein‐induced autoimmune encephalomyelitis

1993 • 61 citations

Characterization of rat encephalitogenic T cells bearing non‐V_β8 T cell recepotors

1992 • 43 citations

Analysis of TCR Vβ gene usage and encephalitogenicity of myelin basic protein peptide p91–103 reactive T cell clones in SJL mice: Lack of evidence for V gene hypothesis

1992 • 30 citations

Clonal diversity of basic protein specific T cells in Lewis rats recovered from experimental autoimmune encephalomyelitis

1991 • 19 citations

Autoimmunity in the Nervous System: Functional Properties of an Encephalitogenic Protein

1989 • 10 citations

Interaction between autoaggressive T Lymphocyte Lines and Their Target Tissues Encephalitogenic T Lymphocytes Destroy Astrocytes Presenting Myelin Basic Protein

1986 • 2 citations