The Development of Rational Strategies for Selective Immunotherapy against Autoimmune Demyelinating Disease

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

HLA and Disease Associations

1985 • 893 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis

1983 • 418 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

1981 • 228 citations

T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice.

1983 • 221 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Regions of allelic hypervariability in the murine Aα immune response gene

1983 • 185 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor

1983 • 165 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Anti I-A antibody suppresses active encephalomyelitis: treatment model for diseases linked to IR genes.

1983 • 160 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 • 147 citations

Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.

1988 • 146 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.

1989 • 135 citations

The T-Cell Receptor Repertoire and Autoimmune Diseases

1989 • 124 citations

Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein.

1987 • 115 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

1986 • 105 citations

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

1989 • 98 citations

HLA AND DISEASE ASSOCIATIONS

1984 • 96 citations

Correlation of T cell receptor V beta gene family with MHC restriction.

1987 • 87 citations

Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy

1989 • 81 citations

Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.

1987 • 73 citations

Allergic encephalomyelitis. Isolation of an encephalitogenic peptide active in the monkey.

1975 • 69 citations

Cellular Basis of Immune Modulation

1990 • 65 citations

Differences in the repertoire of the Lewis rat T cell response to self and non-self myelin basic proteins.

1988 • 58 citations

T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.

1987 • 52 citations

Successful treatment of EAE in rhesus monkeys with MHC class II specific monoclonal antibodies

1988 • 38 citations

Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody☆Decreased accumulation of radiolabelled lymph node cells in the central nervous system

1983 • 37 citations

Inhibition of experimental autoimmune thyroiditis in mice by anti-I-A antibodies

1987 • 34 citations

Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift. Six nonoverlapping epitopes on the HA1 subunit are defined by synthetic peptides.

1989 • 31 citations

Determinants of human myelin basic protein that induce encephalitogenic T cells in Lewis rats.

1989 • 28 citations

Approaches to immunotherapy

1974 • 28 citations

Localization of an enciphalitogenic epitope for the SJL mouse in the N-terminal region of myelin basic protein

1990 • 27 citations

Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire

1992 • 26 citations

Evolution, Function, and Utilization of Major Histocompatibility Complex Polymorphism in Autoimmune Disease

1989 • 7 citations

Genetic influences on neuroimmunologic disease.

1990 • 1 citations