Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Structure of the human type IV collagenase gene.

1990 • 310 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients

1989 • 251 citations

The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

1995 • 227 citations

Cytokine-regulated proteases in autoimmune diseases

1994 • 214 citations

Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.

1992 • 206 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

1996 • 173 citations

Blood-Brain Barrier Abnormalities in Longstanding Multiple Sclerosis Lesions. An Immunohistochemical Study

1994 • 162 citations

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1992 • 134 citations

Stimulation of matrix metalloproteinase‐dependent migration of T cells by eicosanoids

1995 • 128 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Human recombinant interferons‐beta and ‐gamma decrease gelatinase production and invasion by human KG‐2 renal‐carcinoma cells

1994 • 80 citations

Modulation of M_r 72,000 and M_r 92,000 type‐IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma

1994 • 58 citations

Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells

1992 • 51 citations

Pathogenesis of inflammatory demyelination

1995 • 41 citations

Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity

1994 • 21 citations