The Activation of Type 1 and Type 2 Plasminogen by Type I and Type II Tissue Plasminogen Activator

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

1982 • 486 citations

Measurement of the binding of antifibrinolytic amino acids to various plasminogens

1972 • 308 citations

Purification and partial characterization of plasminogen activator from human uterine tissue

1979 • 282 citations

Initial plasmin-degradation of fibrin as the basis of a positive feed-back mechanism in fibrinolysis

1984 • 271 citations

Fibrinolysis in the Animal Organism

1947 • 265 citations

O-Linked fucose and other post-translational modifications unique to EGF modules

1993 • 257 citations

On the interaction of the finger and the kringle-2 domain of tissue-type plasminogen activator with fibrin. Inhibition of kringle-2 binding to fibrin by epsilon-amino caproic acid.

1986 • 239 citations

Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site

1989 • 223 citations

Plasminogen

1992 • 214 citations

Carbohydrate Structures of Human Tissue Plasminogen Activator Expressed in Chinese Hamster Ovary Cells

1989 • 205 citations

Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences

1984 • 176 citations

Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer

1992 • 160 citations

Kinetics of the activation of plasminogen by natural and recombinant tissue-type plasminogen activator.

1984 • 159 citations

Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator

1989 • 157 citations

Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain

1991 • 134 citations

Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit.

1979 • 131 citations

Carbohydrate of the human plasminogen variants. I. Carbohydrate composition, glycopeptide isolation, and characterization.

1979 • 129 citations

Carbohydrate of the human plasminogen variants. II. Structure of the asparagine-linked oligosaccharide unit.

1979 • 128 citations

N-Glycosylation and in vitro enzymic activity of human recombinant tissue plasminogen activator expressed in Chinese hamster ovary cells and a murine cell line

1989 • 111 citations

Effects of N-glycosylation on in vitro activity of Bowes melanoma and human colon fibroblast-derived tissue plasminogen activator

1989 • 89 citations

Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-.ANG. resolution

1992 • 87 citations

Enzyme assays — A practical approach

1992 • 80 citations

Comparative electrophoretic analysis of human and porcine plasminogen activators in sds-polyacrylamide gels containing plasminogen and casein

1983 • 69 citations

Large-scale purification of human tissue-type plasminogen activator using monoclonal antibodies

1985 • 59 citations

alpha-Fucose-mediated binding and degradation of tissue-type plasminogen activator by HepG2 cells.

1994 • 57 citations

Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein.

1990 • 56 citations

Oligosaccharides at each glycosylation site make structure-dependent contributions to biological properties of human tissue plasminogen activator

1991 • 39 citations

Towards improved thrombolytic therapy

1993 • 36 citations

Plasminogen carbohydrate side chains in receptor binding and enzyme activation: A study of C6 glioma cells and primary cultures of rat hepatocytes

1990 • 25 citations

Kringle glycosylation in a modified human tissue plasminogen activator improves functional properties

1993 • 24 citations

Influence of Carbohydrate Side Chains on Activity of Tissue-Type Plasminogen Activator

1986 • 21 citations

The influence of the nature of the asparagine 289-linked oligosaccharide on the activation by urokinase and lysine binding properties of natural and recombinant human plasminogens.

1993 • 19 citations

Allosteric regulation of tPA-mediated plasminogen activation by a modifier mechanism: Evidence for a binding site for plasminogen on the tPA A-chain

1992 • 13 citations

Heterogeneity of human tissue‐type plasminogen activator

1988 • 7 citations