Mechanism and Biological Significance of CD4‐mediated Cytotoxicity

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.

1994 • 626 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

1989 • 487 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.

1992 • 437 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

1994 • 363 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes

1992 • 350 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity

1988 • 322 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

The ups and downs of T cell costimulation

1994 • 240 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

1984 • 209 citations

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane

1992 • 201 citations

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

1991 • 201 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Role of Fas Ligand in Apoptosis Induced by Hepatitis C Virus Infection

1994 • 180 citations

Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses.

1993 • 180 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

1984 • 152 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.

1994 • 133 citations

APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

1993 • 131 citations

Protein-antigen specific Ia-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis.

1985 • 122 citations

The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody

1991 • 119 citations

Expression of specific cytolytic activity by H-2I region-restricted, influenza virus-specific T lymphocyte clones.

1985 • 119 citations

The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is restricted to the DR region of the MHC complex.

1988 • 110 citations

T cells as antigen-presenting cells

1994 • 109 citations

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes.

1991 • 105 citations

The Lyt phenotype of a long‐term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly‐1 cells

1981 • 93 citations

Are MHC class II-restricted cytotoxic T lymphocytes important?

1987 • 90 citations

CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells.

1990 • 86 citations

Comparative accessory cell function of human peripheral blood dendritic cells and monocytes.

1993 • 86 citations

CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

1992 • 85 citations

Expression of two distinct cytolytic mechanisms among murine CD4 subsets.

1990 • 84 citations

Lymphocyte-triggered internal target disintegration

1991 • 75 citations

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

1990 • 73 citations

Complementary roles for CD2 and LFA‐1 adhesion pathways during T cell activation

1991 • 72 citations

Perforin-induced pore formation

1991 • 61 citations

CD2/LFA-3 or LFA-l/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes

1993 • 61 citations

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses

1987 • 58 citations

Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions.

1990 • 56 citations

CD28 ligation by monoclonal antibodies or B7/BB1 provides an accessory signal for the cyclosporin A-resistant generation of cytotoxic T cell activity.

1993 • 56 citations

CD4⁺ T cell‐mediated killing of major histocompatibility complex class II‐positive antigen‐presenting cells (APC) III. CD4⁺ cytotoxic T cells induce apoptosis of APC

1992 • 53 citations

Cytolytic activity of antigen-specific T cells with helper phenotype.

1986 • 50 citations

Helper activity in antigen-specific antibody production mediated by CD4+ human cytotoxic T cell clones directed against herpes simplex virus.

1988 • 48 citations

Induction of I Region-Restricted Hapten-Specific Cytotoxic T Lymphocytes

1977 • 46 citations

Cloned protein antigen-specific, Ia-restricted T cells with both helper and cytolytic activities: Mechanisms of activation and killing

1987 • 46 citations

Human granzyme B is essential for DNA fragmentation of susceptible target cells

1994 • 45 citations

Anergized T cell clones retain their cytolytic ability.

1993 • 44 citations

Distinct pathways of CD4 and CD8 cells induce rapid target DNA fragmentation.

1991 • 39 citations

Metabolic inhibitors distinguish cytolytic activity of CD4 and CD8 clones

1990 • 37 citations

Production of transmembrane and secreted forms of tumor necrosis factor (TNF)-alpha by HIV-1-specific CD4+ cytolytic T lymphocyte clones. Evidence for a TNF-alpha-independent cytolytic mechanism.

1992 • 35 citations

Characterization of antigen-specific, Ia-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity.

1985 • 34 citations

Evidence of a role for TNF-alpha in cytolysis by CD4+, class II MHC-restricted cytotoxic T cells.

1990 • 34 citations

Characterization of T Lymphocyte Subset Alterations by Flow Cytometry in HIV Disease

1993 • 32 citations

The cytotoxic process of CD4 Th1 clones.

1992 • 32 citations

Inducer T-cell-mediated killing of antigen-presenting cells

1986 • 30 citations

Comparing macrophages and dendritic leukocytes as antigen‐presenting cells for humoral responses in vivo by antigen targeting

1994 • 30 citations

Hapten-specific, class II-restricted killing by cloned T cells: direct lysis and production of a cytotoxic factor.

1986 • 25 citations

Fine specificity analysis of human influenza-specific cloned cell lines

1985 • 24 citations

Human CD4+ cytolytic T cells kill antigen-pulsed target T cells by induction of apoptosis.

1993 • 24 citations

Mouse LFA‐3 studied with chimeric soluble CD2 shows preferential expression on lymphoid cells

1991 • 17 citations

AIDS and AIDS-related infections: Current strategies for Prevention and therapy

1990 • 14 citations

Variable requirement for murine lymphocyte function-associated antigen-1 (LFA-1) in T cell-mediated lysis depending upon the tissue origin of the target cells.

1985 • 13 citations

Functional heterogeneity of CD4-positive T-cell subsets: The correlation between effector functions and lymphokine secretion is limited

1991 • 12 citations

Cytostasis of different tumours by a murine PPD-reactive CD4+ T lymphocyte clone is mediated by interferon-gamma and tumour necrosis factor alone or synergistically

1990 • 11 citations

Modulation of lymphokine release and cytolytic activities by activating peripheral blood lymphocytes via CD2.

1990 • 8 citations