The Dendritic Cell System and its Role in Immunogenicity

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 694 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

A Requirement for Two Cell Types for Antibody Formation in vitro

1967 • 612 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain.

1981 • 589 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes

1976 • 510 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

THE INTERACTION OF SOLUBLE HORSERADISH PEROXIDASE WITH MOUSE PERITONEAL MACROPHAGES IN VITRO

1972 • 431 citations

Characterization of nonlymphoid cells derived from rat peripheral lymph

1983 • 343 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

1987 • 237 citations

Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.

1988 • 226 citations

THE ROLE OF AFFERENT LYMPHATICS IN THE REJECTION OF SKIN HOMOGRAFTS

1968 • 224 citations

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

1990 • 210 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

Induction of Fc epsilon R2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon.

1989 • 209 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light‐microscopic immunocytochemical studies of mouse spleen, lymph node, and peyer's patch

1984 • 188 citations

Ia Antigens in Mouse Skin Are Predominantly Expressed on Langerhans Cells

1979 • 185 citations

Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.

1983 • 185 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Studies of the cell surface of mouse dendritic cells and other leukocytes

1981 • 182 citations

Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro.

1984 • 180 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Interdigitating reticulum cells in the human thymus

1974 • 152 citations

Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells.

1990 • 134 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.

1981 • 123 citations

Dendritic Cells as Antigen Presenting Cellsin Vivo

1990 • 104 citations

Induction of murine interleukin 1: stimuli and responsive primary cells.

1987 • 103 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Occurrence of IgE-Bearing Epidermal Langerhans Cells in Atopic Eczema: A Study of the Time Course of the Lesions and With Regard to the IgE Serum Level

1989 • 97 citations

Cells expressing Ia antigens in the avian thymus.

1984 • 93 citations

Distribution and turnover of Langerhans cells during delayed immune responses in human skin.

1987 • 89 citations

Dendritic Cells in the Respiratory Tract

1990 • 85 citations

Large mononuclear (veiled) cells like 'Ia-like' membrane antigens in human afferent lympn.

1980 • 83 citations

The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.

1988 • 81 citations

Characterization of the tissue macrophage and the interstitial dendritic cell as distinct leukocytes normally resident in the connective tissue of rat heart.

1990 • 77 citations

Interleukin 2 receptors on cultured murine epidermal Langerhans cells.

1986 • 75 citations

Interstitial Dendritic Cells

1990 • 67 citations

Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells.

1983 • 61 citations

Characterization of the population of phagocytic cells in thymic cell suspensions

1983 • 60 citations

Thymic Dendritic Cells: Phenotype and Function

1990 • 52 citations

Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen- and antigen-driven primary in vitro T cell responses.

1987 • 48 citations

The Surface of Dendritic Cells in the Mouse as Studied with Monoclonal Antibodies

1990 • 47 citations

Interleukin-1 production by mononuclear cells from rheumatoid synovial effusions

1988 • 42 citations

A novel model for antigen-dependent activation of normal human T cells. Transmembrane signaling by crosslinkage of the CD3/T cell receptor-alpha/beta complex with the cluster determinant 2 antigen.

1990 • 39 citations

Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.

1985 • 37 citations

Reappearance of CD1a Antigenic Sites After Endocytosis on Human Langerhans Cells Evidenced by Immunogoldrelabeling

1989 • 36 citations

Role of dendritic cells in the regulation of class I restricted cytotoxic T lymphocyte responses.

1988 • 31 citations

Lymphokine production by murine T cells in the mixed leukocyte reaction.

1988 • 27 citations

Induction of interleukin 1 alpha mRNA during the antigen-dependent interaction of sensitized T lymphoblasts with macrophages.

1988 • 22 citations

Afferent Lymph Dendritic Cells: A Model for Antigen Capture and Presentationin Vivo

1990 • 21 citations

Comparison of membrane antigens of mouse dendritic cell types

1987 • 21 citations

Human Peripheral Blood‐Derived Dendritic Cells do not Produce Interleukin 1α, Interleukin 1β, or Interleukin 6

1990 • 21 citations

T-cell activation by dendritic cells: CD18-dependent clustering is not sufficient for mitogenesis.

1988 • 16 citations

Murine epidermal Langerhans cells express significant amounts of class I major histocompatibility complex antigens.

1989 • 12 citations

Dendritic Cells in Human Blood and Synovial Exudates

1990 • 9 citations