Functional heterogeneity of CD4-positive T-cell subsets: The correlation between effector functions and lymphokine secretion is limited

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

The isolation and characterization of the human helper inducer T cell subset.

1985 • 708 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

A functional dichotomy in CD4+ T lymphocytes

1988 • 369 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Inhibition of B lymphocyte activation by interferon-gamma.

1987 • 164 citations

Phenotypic and functional heterogeneity of CD4+ T cells

1988 • 142 citations

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

1990 • 141 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

Clonal analysis of functionally distinct human CD4+ T cell subsets.

1988 • 93 citations

CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells.

1990 • 86 citations

Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression.

1985 • 84 citations

The ELISA-plaque assay for the detection and enumeration of antibody-secreting cells

1986 • 80 citations

Two types of functionally distinct, synergizing helper T cells.

1980 • 76 citations

Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

1979 • 60 citations

Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones.

1989 • 57 citations

Accessory cell-dependent selection of specific T-cell functions

1983 • 52 citations

Heterogeneity of helper/inducer T lymphocytes. IV. Stimulation of resting and activated B cells by Th1 and Th2 clones.

1990 • 41 citations

Subtypes of helper cells. Non-inflammatory type 1 helper T cells.

1988 • 40 citations

Functionally distinct helper T cells enriched under different culture conditions cooperate with different B cells.

1982 • 40 citations

Differences in surface phenotype between cytolytic and non-cytolytic CD4+ T cells. MHC class II-specific cytotoxic T lymphocytes lack Leu 8 antigen and express CD2 in high density.

1989 • 24 citations

Evaluation of Ia+ tumor cell lines and peritoneal exudate macrophages as accessory cells: differential requirements for the activation of certain T cell functions.

1983 • 24 citations

Vicia villosa agglutinin separates freshly isolated Peyer's Patch T cells into interleukin 5- or interleukin 2-producing subsets.

1989 • 20 citations

A novel role for interleukin 2 in antibody responses: down-regulation of T helper cell activation.

1987 • 11 citations

Two Distinct Azobenzenearsonate‐Specific Helper T‐Cell Subpopulations Mediate Different Forms of T‐B Cooperation

1983 • 7 citations

Two subsets of cloned t helper cells exhibit different activation requirements and characteristics

1989 • 3 citations

Clonal Expansion and Differentiation to Effector Function in Normal CD4 T Cell Subpopulations

1989 • 3 citations