Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Current protocols in immunology

1992 • 1,464 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO

1974 • 488 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes

1989 • 251 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

1989 • 114 citations

Limiting dilution analysis of alloantigen-reactive T lymphocytes. IV. High frequency of cytolytic T lymphocyte precursor cells in MLC blasts separated by velocity sedimentation.

1980 • 15 citations