Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Damage to mammalian cells by proteins that form transmembrane pores

2005 • 269 citations

Homology of perforin to the ninth component of complement (C9)

1988 • 268 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

1983 • 253 citations

Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes

1989 • 251 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor.

1986 • 241 citations

Serine esterase in cytolytic T lymphocytes

1986 • 240 citations

Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

1987 • 236 citations

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

1983 • 229 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14

1986 • 197 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

The sequence and topology of human complement component C9.

1985 • 179 citations

Isolation and characterization of a serine esterase from cytolytic T cell granules

1986 • 177 citations

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

1987 • 174 citations

Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria.

1987 • 167 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: conjugation, killing and recycling at the single cell level

1975 • 158 citations

Membrane attack by complement

1984 • 156 citations

Granules of cytolytic T-lymphocytes contain two serine esterases.

1986 • 148 citations

Inhibition of human natural cytotoxicity by macromolecular antiproteases.

1981 • 147 citations

Specific release of proteoglycans from human natural killer cells during target lysis

1985 • 146 citations

Killing of target cells by lymphocytes: a mechanistic view.

1989 • 134 citations

Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.

1980 • 133 citations

Cytolytic T Lymphocytes

1983 • 119 citations

Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.

1988 • 118 citations

Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.

1987 • 113 citations

Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.

1986 • 112 citations

Cellular and Humoral Mechanisms of Cytotoxicity: Structural and Functional Analogies

1987 • 111 citations

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

1989 • 110 citations

Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.

1987 • 109 citations

Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis.

1989 • 105 citations

Cytotoxic T lymphocyte mediated cytolysis

1988 • 99 citations

The Isolation and Characterization of a Family of Serine Protease Genes Expressed in Activated Cytotoxic T Lymphocytes

1988 • 95 citations

Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors.

1984 • 95 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection.

1989 • 93 citations

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.

1988 • 92 citations

Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

1988 • 91 citations

Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.

1986 • 89 citations

Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity.

1987 • 89 citations

Established Murine Cytolytic T‐Cell Lines as Tools for a Somatic Cell Genetic Analysis of T‐Cell Functions

1980 • 86 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes

1986 • 83 citations

Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro.

1988 • 79 citations

Mechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.

1986 • 75 citations

Are proteinases functional molecules of T lymphocytes?

1987 • 74 citations

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

1987 • 73 citations

Biochemical and functional properties of serine esterases in acidic cytoplasmic granules of cytotoxic T lymphocytes.

1987 • 70 citations

Identification of granzyme A isolated from cytotoxic T‐lymphocyte‐granules as one of the proteases encoded by CTL‐specific genes

1986 • 68 citations

Appearance of cytolytic granules upon induction of cytolytic activity in CTL-hybrids.

1985 • 65 citations

Cytotoxic granules from killer cells: specificity of granules and insertion of channels of defined size into target membranes.

1985 • 62 citations

Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

1988 • 62 citations

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells

1978 • 60 citations

Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases

1989 • 56 citations

A novel serine proteinase (HuTSP) isolated from a cloned human CD8⁺ cytolytic T cell line is expressed and secreted by activated CD4⁺ and CD8⁺ lymphocytes

1987 • 54 citations

Granzymes: a Family of Serine Proteases in Granules of Cytolytic T Lymphocytes

1988 • 50 citations

Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.

1988 • 49 citations

Resistance of mouse cytolytic cells to pore‐forming protein‐mediated cytolysis

1988 • 41 citations

The most efficient cytotoxic T lymphocytes are the least susceptible to lysis.

1987 • 41 citations

Neoantigen of the Complement Membrane Attack Complex on Cytotoxic Human Peripheral Blood Lymphocytes

1979 • 39 citations

Structure and Function of the Family of Proteoglycans That Reside in the Secretory Granules of Natural Killer Cells and Other Effector Cells of the Immune Response

1988 • 37 citations

Lymphocyte‐Mediated Cytolysis

1988 • 37 citations

Evidence for the involvement of a T-cell-associated serine proteinase (TSP-1) in cell killing

1987 • 37 citations

Resistance of primary CD8+ cytotoxic T lymphocytes to lysis by cytotoxic granules from cloned T cell lines.

1988 • 33 citations

Cellular localization of perforin 1 in murine cloned cytotoxic T lymphocytes.

1987 • 32 citations

The primary structure of the lymphocyte pore-forming protein perforin: Partial amino acid sequencing and determination of isoelectric point

1988 • 31 citations

Release of biologically active fragments from human plasma-fibronectin by murine T cell-specific proteinase 1 (TSP-1).

1988 • 29 citations

A Comparison of the Cytolytic Properties of Murine Primary CD8+ Cytotoxic T Lymphocytes and Cloned Cytotoxic T Cell Lines

1988 • 26 citations

Absence of homologous restriction factor does not affect CTL‐mediated cytolysis

1989 • 25 citations

Isolation of two cDNA sequences which encode cytotoxic cell proteases

1988 • 25 citations

The role of cytoplasmic granule components in cytolutic lymphocyte-mediated cytolysis

1987 • 24 citations

Inhibition of cytotoxic T lymphocyte and natural killer cell-mediated lysis by O,S,S,-trimethyl phosphorodithioate is at an early postrecognition step.

1988 • 22 citations

Induction of expression of cell-surface homologous restriction factor upon anti-CD3 stimulation of human peripheral lymphocytes.

1988 • 20 citations

Granzyme A secretion by normal activated Lyt‐2⁺ and L3T4⁺ T cells in response to antigenic stimulation

1987 • 19 citations

Induction of synthesis of the cytolytic C9 (ninth component of complement)-related protein in human peripheral mononuclear cells by monoclonal antibody OKT3 or interleukin 2: correlation with cytotoxicity and lymphocyte phenotype.

1987 • 18 citations

Target cell lysis by cytotoxic T lymphocytes that lack detectable hemolytic perforin activity.

1988 • 18 citations

The role of lymphotoxin in T-cell-mediated cytotoxicity

1987 • 15 citations

Cytolytic T-Cell Granules: Biochemimcal Properties and Functional Specificity

1985 • 13 citations

Getting nearer the mark

1988 • 10 citations

Identification of a macrophage-activating factor in granules of the RNK large granular lymphocyte leukemia.

1989 • 10 citations

LGL Secretory Granule-Associated, 60-kd BLT Esterase Augments the Lytic Activity of Cytolysin against Nucleated Target Cells1

2015 • 4 citations