The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

THIOREDOXIN

1985 • 1,885 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Molecular and Cellular Aspects of Thiol–Disulfide Exchange

1990 • 763 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1985 • 622 citations

Guide to Yeast Genetics and Molecular Biology

1991 • 607 citations

[20] In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast

1991 • 584 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

[2] Thiol/disulfide exchange equilibria and disulfidebond stability

1995 • 535 citations

Reexamination of the Folding of BPTI: Predominance of Native Intermediates

1991 • 505 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

1990 • 369 citations

Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum.

1992 • 318 citations

Sorting of soluble ER proteins in yeast.

1988 • 270 citations

Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme.

1994 • 267 citations

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

1994 • 261 citations

Disulphide bonds and protein stability

1988 • 261 citations

A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase.

1987 • 241 citations

The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation.

1994 • 241 citations

Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase

1993 • 211 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

Conformational restrictions on the pathway of folding and unfolding of the pancreatic trypsin inhibitor

1977 • 188 citations

Protein disulfide isomerase is both an enzyme and a chaperone

1993 • 157 citations

The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

1992 • 150 citations

The reactivities and ionization properties of the active-site dithiol groups of mammalian protein disulphide-isomerase

1991 • 144 citations

Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity.

1992 • 144 citations

Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast.

1991 • 137 citations

Peptide binding to protein disulfide isomerase occurs at a site distinct from the active sites.

1993 • 129 citations

Independence of the Chaperone Activity of Protein Disulfide Isomerase from Its Thioredoxin-like Active Site

1995 • 124 citations

Oxidation and Disulfide Interchange in the Reactivation of Reduced Ribonuclease

1964 • 124 citations

Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae

1991 • 123 citations

The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase.

1994 • 104 citations

Catalytic Mechanism of DsbA and Its Comparison with That of Protein Disulfide Isomerase

1995 • 95 citations

Effect of protein and peptide inhibitors on the activity of protein disulfide-isomerase

1991 • 87 citations

Studies on the Mechanism of the Enzymic Catalysis of Disulfide Interchange in Proteins

1967 • 84 citations

A glycosylated protoxin in killer yeast: Models for its structure and maturation

1983 • 80 citations

Peptide binding by protein disulfide isomerase, a resident protein of the endoplasmic reticulum lumen.

1991 • 78 citations

Molecular Structure of a Yeast Gene, PDI1, Encoding Protein Disulfide Isomerase That Is Essential for Cell Growth

1991 • 54 citations

<scp>III</scp>. Yeast sequencing reports. Determination of the sequence of the yeast YCL313 gene localized on chromosome III. Homology with the protein disulfide isomerase (PDI gene product) of other organisms

1991 • 54 citations

Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins

1988 • 53 citations

Resolution of protein disulphide-isomerase and glutathione-insulin transhydrogenase activities by covalent chromatography

1980 • 45 citations

Disulfide bond formation and eukaryotic secretory productivity

1995 • 36 citations

Conserved residues flanking the thiol/disulfide centers of protein disulfide isomerase are not essential for catalysis of thiol/disulfide exchange

1992 • 29 citations

Production of Rat Protein Disulfide Isomerase in Saccharomyces cerevisiae

1995 • 17 citations

Reactivation of reduced ribonuclease by rat-liver microsomes and cytochrome c

1966 • 10 citations