Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

Current protocols in molecular biology

1988 • 4,543 citations

Protein folding in the cell

1992 • 4,138 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

1994 • 473 citations

VESICLE-MEDIATED PROTEIN SORTING

1992 • 472 citations

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.

1996 • 455 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

1995 • 400 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

1996 • 385 citations

Sec61p and BiP directly facilitate polypeptide translocation into the ER

1992 • 370 citations

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

1992 • 352 citations

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

1996 • 346 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

1997 • 255 citations

Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.

1992 • 239 citations

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1993 • 205 citations

A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.

1996 • 191 citations

Binding of Secretory Precursor Polypeptides to a Translocon Subcomplex Is Regulated by BiP

1997 • 161 citations

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae

1997 • 151 citations

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.

1993 • 135 citations

The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum.

1993 • 107 citations