Multiple Molecular Chaperones Complex with Misfolded Large Oligomeric Glycoproteins in the Endoplasmic Reticulum

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Protein folding in the cell

1992 • 4,138 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

1987 • 1,122 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.

1994 • 617 citations

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1989 • 491 citations

Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells

1987 • 442 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

Perturbation of cellular calcium induces secretion of luminal ER proteins

1989 • 370 citations

Molecular chaperones in cellular protein folding

1995 • 301 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

1990 • 254 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex.

1984 • 242 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts.

1987 • 195 citations

Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum.

1995 • 194 citations

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.

1992 • 187 citations

The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

1993 • 163 citations

The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences.

1992 • 149 citations

The thrombospondin family

1993 • 139 citations

Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia.

1996 • 128 citations

Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP.

1992 • 112 citations

Post-translational glycosylation-induced activation of aglycoinsulin receptor accumulated during tunicamycin treatment.

1981 • 112 citations

Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation.

1994 • 104 citations

Brefeldin A, thapsigargin, and AlF stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

1992 • 98 citations

Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1.

1994 • 85 citations

BIP—A Heat Shock Protein Involved in Immunoglobulin Chain Assembly

1991 • 81 citations

Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells

1986 • 64 citations

Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum

1994 • 64 citations

[38] Protein disulfide-isomerase

1995 • 52 citations

Disulfide-linked aggregation of thyroglobulin normally occurs during nascent protein folding

1993 • 44 citations

The Adenovirus E1A gene blocks the differentiation of a thyroid epithelial cell line, however the neoplastic phenotype is achieved only after cooperation with other oncogenes.

1993 • 44 citations

Folding, Assembly, and Posttranslational Modification of Proteins within the Lumen of the Endoplasmic Reticulum

1993 • 39 citations

Thyrotropin regulation of sialic acid expression in rat thyroid cells.

1993 • 38 citations

Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells.

1993 • 25 citations

Effects of tunicamycin on the expression of beta-adrenergic receptors in human astrocytoma cells during growth and recovery from agonist-induced down-regulation.

1985 • 21 citations

EFFECT OF ACTINOMYCIN D ON TSH-INDUCED STIMULATION OF THYROIDAL PROTEIN SYNTHESIS IN THE RAT

1974 • 14 citations