Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

THIOREDOXIN

1985 • 1,885 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Regulation of CO2 assimilation in oxygenic photosynthesis: The ferredoxin/thioredoxin system

1991 • 393 citations

Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli.

1980 • 364 citations

Structural and functional relations among thioredoxins of different species

1991 • 363 citations

Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action.

1979 • 324 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Thioredoxin. 6. The Amino Acid Sequence of the Protein from Escherichia coli B

1968 • 274 citations

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

1994 • 261 citations

Cloning and expression of a cDNA for human thioredoxin.

1988 • 239 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

Conformational and functional similarities between glutaredoxin and thioredoxins.

1984 • 205 citations

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione

1993 • 162 citations

Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox capacity of thioredoxin is not required for stimulation of DNA polymerase activity.

1986 • 146 citations

The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin

1994 • 143 citations

High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution

1991 • 141 citations

The Nuclear Magnetic Resonance Solution Structure of the Mixed Disulfide between Escherichia coli Glutaredoxin(C14S) and Glutathione

1994 • 140 citations

Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using nitrogen-15 NMR relaxation measurements

1993 • 119 citations

Relationship between electrostatics and redox function in human thioredoxin: characterization of pH titration shifts using two-dimensional homo- and heteronuclear NMR

1992 • 109 citations

Degenerate intermolecular thiolate-disulfide interchange involving cyclic five-membered disulfides is faster by .apprx.103 than that involving six- or seven-membered disulfides

1990 • 104 citations

Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold

1989 • 88 citations

Determination of the pKa values of active-center cysteines, cysteines-32 and -35, in Escherichia coli thioredoxin by Raman spectroscopy

1993 • 80 citations

Thioredoxin. A Localized Conformational Change Accompanying Reduction of the Protein to the Sulfhydryl Form^*

1967 • 72 citations

Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional proton NMR

1991 • 64 citations

A mutant thioredoxin from Escherichia coli tsnC 7007 that is nonfunctional as subunit of phage T7 DNA polymerase.

1981 • 42 citations

Crystallization and preliminary crystallographic data for thioredoxin from Escherichia coli B

1970 • 37 citations

High-resolution three-dimensional structure of reduced recombinant human thioredoxin in solution.

1991 • 31 citations

1H and15N resonance assignments and secondary structure of the human thioredoxin C62A, C69A, C73A mutant

1992 • 25 citations

ChemInform Abstract: Degenerate Intermolecular Thiolate-Disulfide Interchange Involving Cyclic Five-Membered Disulfides is Faster by ≅103 Than That Involving Six- or Seven-Membered Disulfides

1990 • 5 citations