The formation of protein disulphide bonds

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Folding and Assembly of Viral Membrane Proteins

1993 • 447 citations

Mutations that Allow Disulfide Bond Formation in the Cytoplasm of Escherichia coli

1993 • 420 citations

Crystal structure of the DsbA protein required for disulphide bond formation in vivo

1993 • 387 citations

Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation

1993 • 342 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

The reactive and destabilizing disulfide bond of DsbA, a protein required for protein disulfide bond formation in vivo

1993 • 273 citations

The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation.

1994 • 241 citations

Reactivity and Ionization of the Active Site Cysteine Residues of DsbA, a Protein Required for Disulfide Bond Formation in vivo

1994 • 239 citations

Building bridges: disulphide bond formation in the cell

1994 • 213 citations

Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase

1993 • 211 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

Protein Disulfide Isomerase Overexpression Increases Secretion of Foreign Proteins in Saccharomyces cerevisiae

1994 • 194 citations

Protein folding in the periplasm of Escherichia coli

1994 • 175 citations

Characterization of DsbC, a periplasmic protein of Erwinia chrysanthemi and Escherichia coli with disulfide isomerase activity.

1994 • 170 citations

Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.

1994 • 147 citations

Membrane glycoprotein folding, oligomerization and intracellular transport: effects of dithiothreitol in living cells.

1993 • 139 citations

The bonds that tie: Catalyzed disulfide bond formation

1993 • 134 citations

The secretory pathway is normal in dithiothreitol-treated cells, but disulfide-bonded proteins are reduced and reversibly retained in the endoplasmic reticulum.

1993 • 129 citations

Structural characterization of the disulfide folding intermediates of bovine .alpha.-lactalbumin

1993 • 118 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

The Redox Properties of Protein Disulfide Isomerase (DsbA) of Escherichia coli Result from a Tense Conformation of its Oxidized Form

1993 • 112 citations

Pathway of disulfide-coupled unfolding and refolding of bovine .alpha.-lactalbumin

1993 • 109 citations

Catalytic Mechanism of DsbA and Its Comparison with That of Protein Disulfide Isomerase

1995 • 95 citations

Effects of DsbA on the Disulfide Folding of Bovine Pancreatic Trypsin Inhibitor and .alpha.-Lactalbumin

1994 • 92 citations

Oxidative refolding of IGF-1 yields two products of similar thermodynamic stability: A bifurcating protein-folding pathway

1993 • 90 citations

Dissecting the Disulphide-coupled Folding Pathway of Bovine Pancreatic Trypsin Inhibitor

1993 • 90 citations

Ribonuclease A can be transformed into a dimeric ribonuclease with antitumor activity

1994 • 87 citations

Bacterial protein disulfide isomerase: Efficient catalysis of oxidative protein folding at acidic pH

1993 • 86 citations

Dissecting the Mechanism of Protein Disulfide Isomerase: Catalysis of Disulfide Bond Formation in a Model Peptide

1994 • 83 citations

The disulfide folding pathway of potato carboxypeptidase inhibitor.

1994 • 80 citations

On the Biosynthesis of Bovine Pancreatic Trypsin Inhibitor (BPTI)

1993 • 80 citations

Correctly Folded T-cell Receptor Fragments in the Periplasm of Escherichia coli

1994 • 76 citations

Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase

1993 • 75 citations

Post-translational folding of influenza hemagglutinin in isolated endoplasmic reticulum-derived microsomes.

1993 • 71 citations

Chaperone function of calnexin for the folding intermediate of gp80, the major secretory protein in MDCK cells. Regulation by redox state and ATP.

1994 • 65 citations

Role of interchain disulfide bonds on the assembly and secretion of human fibrinogen.

1994 • 58 citations

Disulfide bond mutations affect the folding of the human chorionic gonadotropin-beta subunit in transfected Chinese hamster ovary cells

1993 • 53 citations

Replacement of the Active-Site Cysteine Residues of DsbA, a Protein Required for Disulfide Bond Formation in vivo

1994 • 52 citations

Structural Characterization of a Three-Disulfide Intermediate of Ribonuclease a Involved in both the Folding and Unfolding Pathways

1994 • 48 citations

Disulfide-linked aggregation of thyroglobulin normally occurs during nascent protein folding

1993 • 44 citations

Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor

1993 • 36 citations

Amino acid replacement that eliminates kinetic traps in the folding pathway of pancreatic trypsin inhibitor

1993 • 36 citations

The folding of bovine pancreatic trypsin inhibitor in the Escherichia coli periplasm.

1994 • 35 citations

A model catalyst of protein disulphide bond formation

1993 • 23 citations

Dithiothreitol treatment induces heterotypic aggregation of newly synthesized secretory proteins in HepG2 cells.

1994 • 22 citations

Analysis of RNase A refolding intermediates by electrospray/mass spectrometry

1994 • 21 citations

Protein Folding: Folding helpers and unhelpful folders

1994 • 21 citations

A Misfolded but Active Dimer of Bovine Seminal Ribonuclease

1994 • 20 citations

Production of disulfide‐linked hirudin dimer by in vitro folding

1993 • 8 citations