Complex, Two-way Traffic of Molecules Across the Membrane of the Endoplasmic Reticulum

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

Quality control in the secretory pathway

1995 • 679 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

TOPOGRAPHY OF GLYCOSYLATION IN THE ROUGH ENDOPLASMIC RETICULUM AND GOLGI APPARATUS

1987 • 596 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

What drives the translocation of proteins?

1992 • 415 citations

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1997 • 412 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

Role of Cue1p in Ubiquitination and Degradation at the ER Surface

1997 • 386 citations

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast.

1996 • 385 citations

Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

1998 • 365 citations

Enzymatic conversion of proteins to glycoproteins.

1977 • 295 citations

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

1997 • 295 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Endoplasmic reticulum degradation: reverse protein flow of no return

1997 • 256 citations

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

1997 • 255 citations

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase

1996 • 253 citations

Topography of glycosylation reactions in the endoplasmic reticulum

1992 • 237 citations

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol

1997 • 227 citations

Cytosolic Degradation of T-cell Receptor α Chains by the Proteasome

1997 • 220 citations

Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm.

1988 • 213 citations

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

1994 • 207 citations

Primary structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins. Studies with natural and synthetic peptides.

1979 • 197 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

The α Chain of the T Cell Antigen Receptor Is Degraded in the Cytosol

1997 • 166 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Protein Transport by Purified Yeast Sec Complex and Kar2p Without Membranes

1997 • 146 citations

Protein glycosylation in the endoplasmic reticulum: current topological issues

1987 • 107 citations

Toxin entry: how reversible is the secretory pathway?

1992 • 107 citations

Identification of Peptide:N-Glycanase Activity in Mammalian-Derived Cultured Cells

1993 • 102 citations

Post-translational protein translocation: not all hsc70s are created equal

1996 • 100 citations

Release of glucose-containing polymannose oligosaccharides during glycoprotein biosynthesis. Studies with thyroid microsomal enzymes and slices.

1983 • 98 citations

Bidirectional movement of a nascent polypeptide across microsomal membranes reveals requirements for vectorial translocation of proteins

1992 • 93 citations

Site-specific de- N -glycosylation of diglycosylated ovalbumin in hen oviduct by endogenous peptide: N -glycanase as a quality control system for newly synthesized proteins

1997 • 87 citations

Intracellular compartmentalization and degradation of free polymannose oligosaccharides released during glycoprotein biosynthesis.

1994 • 84 citations

Principles of selective transport: coat complexes hold the key

1996 • 84 citations

Transporter Associated with Antigen Processing**This article was accepted for publication on 1 October 1996.

1997 • 83 citations

Transfer of Free Polymannose-type Oligosaccharides from the Cytosol to Lysosomes in Cultured Human Hepatocellular Carcinoma HEPG2 Cells

1997 • 77 citations

Endoplasmic reticulum-to-cytosol transport of free polymannose oligosaccharides in permeabilized HepG2 cells.

1995 • 75 citations

Approaching the mechanism of protein transport across the ER membrane

1996 • 74 citations

Potential regulation of N-glycosylation precursor through oligosaccharide-lipid hydrolase action and glucosyltransferase-glucosidase shuttle.

1991 • 70 citations

Catabolism of glycan moieties of lipid intermediates leads to a single Man₅GlcNAc oligosaccharide isomer: a study with permeabilized CHO cells

1995 • 58 citations

Demonstration and cytosolic location of an endo-N-acetyl-β-D-glucosaminidase activity towards an asialo-N-acetyl-lactosaminic-type substrate in rat liver

1980 • 56 citations

Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae.

1992 • 52 citations

Heat shock-induced prompt glycosylation. Identification of P-SG67 as calreticulin.

1994 • 52 citations

Release of oligomannoside-type glycans as a marker of the degradation of newly synthesized glycoproteins

1994 • 49 citations

Identification and Distribution of Peptide:N-Glycanase (PNGase) in Mouse Organs

1995 • 48 citations

Demonstration of a peptide:N-glycosidase in the endoplasmic reticulum of rat liver

1997 • 47 citations

Occurrence of a cytosolic neutral chitobiase activity involved in oligomannoside degradation: a study with Madin-Darby bovine kidney (MDBK) cells

1996 • 47 citations

Protein translocation at the ER membrane: A complex process becomes more so

1997 • 46 citations

N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins

1995 • 44 citations

Similar processes mediate glycopeptide export from the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae

1997 • 42 citations

In vivo N-glycosylation and fate of Asn-X-Ser/Thr tripeptides.

1990 • 34 citations

Protein degradation: The ins and outs of the matter

1997 • 33 citations

Characterization of an oligosaccharide-pyrophosphodolichol pyrophosphatase activity in yeast.

1988 • 30 citations

Oligomannosides or oligosaccharide-lipids as potential substrates for rat liver cytosolic α-<scp>d</scp>-mannosidase

1996 • 29 citations

Heat Stress-induced Protein Glycosylation in Mammalian Cells.

1995 • 16 citations

Free Oligomannosides Produced during the N-Glycosylation Process: Origin, Intracellular Trafficking and Putative Roles.

1997 • 13 citations

Glycotripeptides are released by yeast but not by mammalian microsomes

1994 • 8 citations

X-線結晶解析が示した分岐糖鎖架橋分子としての動物レクチン(ガレクチン-1)のりアリティー

1995 • 1 citations