A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress

Rho GTPases in cell biology

2002 • 4,662 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Homing and cellular traffic in lymph nodes

2003 • 1,233 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

2006 • 1,092 citations

Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes

2006 • 907 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

2006 • 795 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in theplt/pltmouse

2000 • 580 citations

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

2002 • 569 citations

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

2005 • 561 citations

Sphingosine 1-Phosphate, a Key Cell Signaling Molecule

2002 • 551 citations

The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors

2004 • 532 citations

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

2001 • 443 citations

Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

2004 • 436 citations

The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

2000 • 420 citations

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

2002 • 405 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

2003 • 380 citations

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

2005 • 318 citations

Intravital Microscopy

2004 • 289 citations

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

2005 • 278 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Chemokine control of lymphocyte trafficking: a general overview

2005 • 247 citations

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

2005 • 235 citations

Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality duringN-formyl-Met-Leu-Phe-induced chemotaxis

2002 • 235 citations

Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells

2002 • 229 citations

Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing

2004 • 226 citations

Differential Requirements for DOCK2 and Phosphoinositide-3-Kinase γ during T and B Lymphocyte Homing

2004 • 224 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

Rgs1 and Gnai2 Regulate the Entrance of B Lymphocytes into Lymph Nodes and B Cell Motility within Lymph Node Follicles

2005 • 195 citations

Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

2003 • 185 citations

Stop and Go Traffic to Tune T Cell Responses

2004 • 143 citations

The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC

2001 • 139 citations

Genetic defect in T lymphocyte‐specific homing into peripheral lymph nodes

1997 • 138 citations

The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

2005 • 137 citations

Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate

2002 • 129 citations

Do phosphoinositide 3-kinases direct lymphocyte navigation?

2003 • 121 citations

DOCK2 Is Essential for Antigen-Induced Translocation of TCR and Lipid Rafts, but Not PKC-θ and LFA-1, in T Cells

2003 • 116 citations

A stochastic view of lymphocyte motility and trafficking within the lymph node

2003 • 115 citations

The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell–expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches

2005 • 110 citations

CXCL12 Mediates CCR7-independent Homing of Central Memory Cells, But Not Naive T Cells, in Peripheral Lymph Nodes

2004 • 110 citations

Cutting Edge: The B Cell Chemokine CXC Chemokine Ligand 13/B Lymphocyte Chemoattractant Is Expressed in the High Endothelial Venules of Lymph Nodes and Peyer’s Patches and Affects B Cell Trafficking Across High Endothelial Venules

2003 • 105 citations

Egress: a receptor‐regulated step in lymphocyte trafficking

2003 • 102 citations

Dynamic Behavior of T Cells and Thymocytes in Lymphoid Organs as Revealed by Two-Photon Microscopy

2004 • 99 citations

CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen

2005 • 94 citations

From rafts to crafts: membrane asymmetry in moving cells

2003 • 91 citations

Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes

2005 • 90 citations

The CDM protein DOCK2 in lymphocyte migration

2002 • 87 citations

Illuminating the Landscape of In Vivo Immunity

2004 • 78 citations

Homeostatic Lymphoid Chemokines Synergize with Adhesion Ligands to Trigger T and B Lymphocyte Chemokinesis

2006 • 77 citations

DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration

2006 • 76 citations

The Rap GTPases mediate CXCL13‐ and sphingosine1‐phosphate‐induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes

2006 • 53 citations

Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

2005 • 46 citations