Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors

2000 • 835 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal Sorting

2001 • 456 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2

2003 • 300 citations

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

2005 • 235 citations

Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

1999 • 180 citations

Differential β-Arrestin Trafficking and Endosomal Sorting of Somatostatin Receptor Subtypes

2004 • 163 citations

Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

2006 • 156 citations

Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors

2001 • 135 citations

c-Cbl Mediates Ubiquitination, Degradation, and Down-regulation of Human Protease-activated Receptor 2

2005 • 130 citations

Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination

2003 • 127 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

Transmembrane Signaling by G Protein-Coupled Receptors

2006 • 113 citations

Regulated ubiquitination of proteins in GPCR-initiated signaling pathways

2003 • 109 citations

AP2 Clathrin Adaptor Complex, but Not AP1, Controls the Access of the Major Histocompatibility Complex (MHC) Class II to Endosomes

2005 • 98 citations

Quantitation of the lysosomotropic character of cationic amphiphilic drugs using the fluorescent basic amine Red DND-99

2004 • 95 citations

Ubiquitin and endocytic protein sorting

2005 • 94 citations

Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes

2005 • 90 citations

The S1P2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function

2006 • 85 citations

Lysophospholipid Receptors as Potential Drug Targets in Tissue Transplantation and Autoimmune Diseases

2005 • 79 citations

Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4

2006 • 72 citations

Ubiquitin and endocytic protein sorting

2005 • 61 citations

Intracellular Protein Degradation: From a Vague Idea Thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting^*

2006 • 59 citations

CD69 down‐modulation and inhibition of thymic egress by short‐ and long‐term selective chemical agonism of sphingosine 1‐phosphate receptors

2005 • 56 citations

Novel roles for arrestins in the post-endocytic trafficking of G protein-coupled receptors

2004 • 52 citations

Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway

2005 • 48 citations

Resistance of the Human β1-Adrenergic Receptor to Agonist-induced Ubiquitination

2004 • 32 citations

Ubiquitination of G-Protein-Coupled Receptors

2004 • 17 citations