Essential Requirement for Sphingosine Kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Cellular response to endoplasmic reticulum stress: a matter of life or death

2006 • 659 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

2005 • 606 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

Sphingosine in apoptosis signaling

2002 • 320 citations

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

2005 • 292 citations

Sphingosine Kinase: Biochemical and Cellular Regulation and Role in Disease

2006 • 273 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

2004 • 261 citations

Sphingolipid Transport: Rafts and Translocators

2002 • 223 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

2002 • 191 citations

A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

2003 • 151 citations

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

2003 • 147 citations

The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

2005 • 137 citations

Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?

2004 • 133 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus.

2002 • 120 citations

FTY720 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Drug Resistance

2005 • 99 citations

Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert

2004 • 86 citations

Immunosuppressant FTY720 Induces Apoptosis by Direct Induction of Permeability Transition and Release of Cytochrome c from Mitochondria

2000 • 85 citations

Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma

2005 • 82 citations

Lysophospholipid receptor‐dependent and ‐independent calcium signaling

2004 • 82 citations

Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell‐cycle entry and apoptosis

2001 • 78 citations

FTY720, a fungus metabolite, inhibits in vivo growth of androgen‐independent prostate cancer

2005 • 77 citations

Sphingosine-dependent Protein Kinase-1, Directed to 14-3-3, Is Identified as the Kinase Domain of Protein Kinase Cδ

2003 • 71 citations

The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720

1997 • 68 citations

Evidence that FTY720 induces T cell apoptosis in vivo

2000 • 59 citations

Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells

2001 • 58 citations

Fluorescence-based assay of sphingosine kinases

2004 • 53 citations

FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing

1999 • 49 citations

Sphingosine Contributes to Glucocorticoid-Induced Apoptosis of Thymocytes Independently of the Mitochondrial Pathway

2004 • 49 citations

FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects

2001 • 43 citations

Endogenous Substrates of Sphingosine-Dependent Kinases (SDKs) Are Chaperone Proteins: Heat Shock Proteins, Glucose-Regulated Proteins, Protein Disulfide Isomerase, and Calreticulin

1999 • 39 citations

T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2

2002 • 37 citations

Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate

2005 • 26 citations

Genetic, Biochemical, and Transcriptional Responses of Saccharomyces cerevisiae to the Novel Immunomodulator FTY720 Largely Mimic Those of the Natural Sphingolipid Phytosphingosine

2004 • 25 citations

Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells

2004 • 20 citations

Study of T-cell signaling by somatic cell mutagenesis and complementation cloning

2003 • 12 citations

NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies

2005 • 9 citations