FTY720 suppresses humoral immunity by inhibiting germinal center reaction

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Lysophospholipids--Receptor Revelations

2001 • 539 citations

FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory

2000 • 364 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

2002 • 265 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

1998 • 263 citations

FTY720: ALTERED LYMPHOCYTE TRAFFIC RESULTS IN ALLOGRAFT PROTECTION

2001 • 175 citations

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

2000 • 172 citations

Antigen Drives Very Low Affinity B Cells to Become Plasmacytes and Enter Germinal Centers

1998 • 169 citations

FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

2000 • 166 citations

Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production

2000 • 135 citations

Immunosuppressant FTY720 inhibits thymocyte emigration

2000 • 135 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.

1996 • 127 citations

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

2003 • 124 citations

Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells

2003 • 119 citations

Enhanced Differentiation of Splenic Plasma Cells but Diminished Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice

2003 • 109 citations

Egress: a receptor‐regulated step in lymphocyte trafficking

2003 • 102 citations

IMMUNOSUPPRESSIVE EFFECTS OF FTY720 ALONE OR IN COMBINATION WITH CYCLOSPORINE AND/OR SIROLIMUS1

1998 • 101 citations

FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing

1999 • 49 citations

Induction of lymphocyte apoptosis and prolongation of allograft survival by FTY720.

1996 • 25 citations

CD4-deficient T helper cells are capable of supporting somatic hypermutation and affinity maturation of germinal center B cells

2002 • 12 citations