Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Extracellular-signal-regulated kinase signalling in neurons

1999 • 554 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

2000 • 419 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells

2001 • 371 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

New Signaling Pathways for Hormones and Cyclic Adenosine 3′,5′-Monophosphate Action in Endocrine Cells

2001 • 357 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway

2001 • 346 citations

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

2000 • 336 citations

Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

2001 • 333 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

2001 • 311 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Differential Signaling of Cyclic AMP

2002 • 281 citations

Regulation of Raf-1 activation and signalling by dephosphorylation

2002 • 277 citations

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

2002 • 276 citations

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

1999 • 262 citations

The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

2000 • 259 citations

PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1

2002 • 245 citations

The ERK Signaling Cascade Inhibits Gonadotropin-stimulated Steroidogenesis

2001 • 239 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

A Novel Mitogen-activated Protein Kinase Phosphatase. STRUCTURE, EXPRESSION, AND REGULATION

1995 • 233 citations

Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase

1995 • 223 citations

Differential Effects of cAMP in Neurons and Astrocytes

1999 • 222 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity

1998 • 219 citations

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

2001 • 219 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

2000 • 210 citations

The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation

2001 • 208 citations

New Signaling Pathways for Hormones and Cyclic Adenosine 3',5'-Monophosphate Action in Endocrine Cells

2001 • 205 citations

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

1999 • 204 citations

cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation

1997 • 200 citations

Cyclic AMP Inhibits Akt Activity by Blocking the Membrane Localization of PDK1

2001 • 186 citations

Interleukin-6- and Cyclic AMP-Mediated Signaling Potentiates Neuroendocrine Differentiation of LNCaP Prostate Tumor Cells

2001 • 183 citations

Rap1 GTPase-activating Protein SPA-1 Negatively Regulates Cell Adhesion

1999 • 175 citations

Ras and Rap1: Two Highly Related Small GTPases with Distinct Function

1999 • 175 citations

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf

2000 • 174 citations

Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses

2002 • 172 citations

Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK

2000 • 171 citations

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

1995 • 161 citations

cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons

2001 • 158 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

2001 • 155 citations

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

1999 • 153 citations

A Novel Regulatory Mechanism of Map Kinases Activation and Nuclear Translocation Mediated by Pka and the Ptp-Sl Tyrosine Phosphatase

1999 • 149 citations

Calcium and cAMP Signals Differentially Regulate cAMP-responsive Element-binding Protein Function via a Rap1-Extracellular Signal-regulated Kinase Pathway

2000 • 145 citations

Suppression of Ras-Induced Transformation of NIH 3T3 Cells by Activated Gα _S

1994 • 139 citations

The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP

2000 • 135 citations

Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.

1998 • 132 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A

2001 • 130 citations

Protein Kinase A-independent Activation of ERK and H,K-ATPase by cAMP in Native Kidney Cells

2002 • 128 citations

Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen‐activated protein kinase

1994 • 125 citations

Dephosphorylation of Ser-259 Regulates Raf-1 Membrane Association

2002 • 121 citations

Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.

1991 • 119 citations

A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells

1996 • 118 citations

New Signaling Pathway for Parathyroid Hormone and Cyclic AMP Action on Extracellular-regulated Kinase and Cell Proliferation in Bone Cells

2002 • 116 citations

Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells.

1999 • 109 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Serum- and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf

2001 • 102 citations

Cyclic AMP Inhibits Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase/Akt Pathways by Inhibiting Rap1

2001 • 101 citations

Cell Type-specific Regulation of B-Raf Kinase by cAMP and 14-3-3 Proteins

2000 • 101 citations

cAMP signaling selectively influences Ras effectors pathways

2001 • 98 citations

β3- and α1-Adrenergic Erk1/2 Activation Is Src- but Not Gi-mediated in Brown Adipocytes

2000 • 95 citations

cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition

1996 • 95 citations

Thyrotropin Activates Mitogen-Activated Protein Kinase Pathway in FRTL-5 by a cAMP-Dependent Protein Kinase A-Independent Mechanism

2001 • 93 citations

Activation of p59Fyn Leads to Melanocyte Dedifferentiation by Influencing MKP-1-regulated Mitogen-activated Protein Kinase Signaling

2002 • 90 citations

Parathyroid Hormone Activates Mitogen-activated Protein Kinase via a cAMP-mediated Pathway Independent of Ras

1997 • 90 citations

Rheb Interacts with Raf-1 Kinase and May Function To Integrate Growth Factor- and Protein Kinase A-Dependent Signals

1997 • 87 citations

Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts

1997 • 87 citations

Rap1 Is Activated by Erythropoietin or Interleukin-3 and Is Involved in Regulation of β1 Integrin-mediated Hematopoietic Cell Adhesion

2001 • 85 citations

Analysis of the Gs/Mitogen-activated Protein Kinase Pathway in Mutant S49 Cells

1998 • 82 citations

Parathyroid Hormone Activates Mitogen-Activated Protein Kinase in Opossum Kidney Cells

1999 • 77 citations

On the mitogenic properties of Rap1b: cAMP-induced G ₁ /S entry requires activated and phosphorylated Rap1b

2002 • 75 citations

Requirement of Ras for the Activation of Mitogen-Activated Protein Kinase by Calcium Influx, cAMP, and Neurotrophin in Hippocampal Neurons

2001 • 75 citations

Activation of the CAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression

1999 • 72 citations

S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3

2001 • 72 citations

Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

2000 • 65 citations

Induction of p21WAF1 expression via Sp1-binding sites by tamoxifen in estrogen receptor-negative lung cancer cells

2000 • 62 citations

Protein Kinase A Regulates Expression of p27 and Cyclin D3 to Suppress Proliferation of Leukemic T Cell Lines

2001 • 62 citations

Cyclic AMP activates Ras

2000 • 62 citations

AP1 Proteins Mediate the cAMP Response of the Dopamine β-Hydroxylase Gene

1998 • 58 citations

Activation of the Small G Protein Rap1 in Dog Thyroid Cells by Both cAMP-Dependent and -Independent Pathways

2000 • 58 citations

cAMP cascade leads to Ras activation in cortical neurons

2000 • 57 citations

Raf‐1 and B‐Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

1999 • 55 citations

Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase

2000 • 54 citations

Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation

2000 • 53 citations

The role of cAMP in regulating tumour cell growth.

1986 • 46 citations

Cyclic AMP‐elevating agents induce the expression of MAP kinase phosphatase‐1 in PC12 cells

2000 • 42 citations

cAMP Protection of Pancreatic Cancer Cells against Apoptosis Induced by ERK Inhibition

2001 • 42 citations

The Localization and Activity of cAMP-dependent Protein Kinase Affect Cell Cycle Progression in Thyroid Cells

2000 • 42 citations

cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation

2000 • 39 citations

Involvement of Mitogen-Activated Protein Kinase in Cyclic Adenosine 3′,5′-Monophosphate-Induced Hormone Gene Expression in Rat Pituitary GH3 Cells*

2001 • 38 citations

Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors

2000 • 37 citations

Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase

1999 • 36 citations

Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3′,5′-Monophosphate Effects on Prolactin Promoter Activity

2001 • 36 citations

Paradoxical accumulation of the cyclin-dependent kinase inhibitor p27kip1 during the cAMP-dependent mitogenic stimulation of thyroid epithelial cells

1996 • 36 citations

Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells

1999 • 35 citations

Stimulatory and inhibitory effects of adenosine A 2A receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells

2000 • 31 citations

Coupling of cAMP/PKA and MAPK Signaling in Neuronal Cells Is Dependent on Developmental Stage

2001 • 30 citations

Pertussis Toxin Inhibits Cholecystokinin- and Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Activation by Disinhibition of the cAMP Signaling Pathway and Inhibition of c-Raf-1

2000 • 29 citations

Cyclic AMP‐Dependent Activation of the Proenkephalin Gene Requires Phosphorylation of CREB at Serine‐133 and a Src‐Related Kinase

1999 • 28 citations

Cyclic AMP Inhibits PDGF-stimulated Mitogen-activated Protein Kinase Activity in Rat Aortic Smooth Muscle Cells via Inactivation of c-Raf-1 Kinase and Induction of MAP Kinase Phosphatase-1

1997 • 28 citations

Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells

2000 • 21 citations

Parathyroid Hormone Activates Mitogen-Activated Protein Kinase in Opossum Kidney Cells

1999 • 21 citations

Cyclic AMP Stimulates the Phosphorylation and Activation of p42 and p44 Mitogen-Activated Protein Kinases in 3T3-F442A Preadipocytes

1996 • 19 citations

Involvement of Mitogen-Activated Protein Kinase in Cyclic Adenosine 3',5'-Monophosphate-Induced Hormone Gene Expression in Rat Pituitary GH3 Cells

2001 • 13 citations

Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3',5'-Monophosphate Effects on Prolactin Promoter Activity

2001 • 13 citations

EFFECTS OF cAMP ON ERK MITOGEN‐ACTIVATED PROTEIN KINASE ACTIVITY IN HEPATOCYTES DO NOT PARALLEL THE BIDIRECTIONAL REGULATION OF DNA SYNTHESIS

1999 • 11 citations

Differential signaling cascade of MAP kinase and S6 kinase depends on 3′,5′-monophosphate concentration in Schwann cells: correlation to cellular differentiation and proliferation

1998 • 10 citations

cAMP inhibits linoleic acid-induced growth by antagonizing p27kip1 depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities

1998 • 8 citations

Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells

1999 • 8 citations