Thyrotropin Activates Mitogen-Activated Protein Kinase Pathway in FRTL-5 by a cAMP-Dependent Protein Kinase A-Independent Mechanism

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

The Thyrotropin Receptor in Thyroid Diseases

1997 • 246 citations

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

2000 • 239 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

Signalling pathways: Jack of all cascades

1996 • 186 citations

Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation

1999 • 186 citations

Ras and Rap1: Two Highly Related Small GTPases with Distinct Function

1999 • 175 citations

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

2000 • 163 citations

Mitogenic and oncogenic properties of the small G protein Rap1b

1998 • 140 citations

The G‐protein‐coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1

2000 • 136 citations

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

2000 • 130 citations

Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A

2001 • 130 citations

Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway

1999 • 121 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

Selective Regulation of Gq Signaling by G Protein-Coupled Receptor Kinase 2: Direct Interaction of Kinase N Terminus with Activated Gαq

2000 • 115 citations

Activation of the Small GTPase Rap1 in Human Neutrophils

1998 • 98 citations

Thyroid-stimulating Hormone and Cyclic AMP Activate p38 Mitogen-activated Protein Kinase Cascade

2000 • 89 citations

Activation of Cyclic AMP-Dependent Kinase Is Required but May Not Be Sufficient To Mimic Cyclic AMP-Dependent DNA Synthesis and Thyroglobulin Expression in Dog Thyroid Cells

1997 • 88 citations

Differential Effects of Protein Kinase A on Ras Effector Pathways

1998 • 73 citations

Differential Effects of Cyclic Adenosine 3′,5′-Monophosphate on p70 Ribosomal S6 Kinase¹

1998 • 72 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Cyclic AMP activates Ras

2000 • 62 citations

Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

1995 • 60 citations

Activation of the Small G Protein Rap1 in Dog Thyroid Cells by Both cAMP-Dependent and -Independent Pathways

2000 • 58 citations

Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras

1999 • 47 citations

GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response.

1996 • 42 citations

Stimulation of Mitogen-activated Protein Kinase by Thyrotropin in Primary Cultured Human Thyroid Follicles

1995 • 41 citations

Inhibition of thyrotropin-stimulated DNA synthesis by microinjection of inhibitors of cellular Ras and cyclic AMP-dependent protein kinase.

1993 • 36 citations

GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor- stimulated response

1996 • 22 citations

Mutations of thyrotropin receptor gene

1997 • 21 citations

Differential Effects of Cyclic Adenosine 3',5'-Monophosphate on p70 Ribosomal S6 Kinase

1998 • 18 citations