Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Hormonal Control of Gene Expression in the Ovary

1994 • 843 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

The Insulin-Related Ovarian Regulatory System in Health and Disease

1999 • 797 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Epithelial sodium channel regulated by aldosterone-induced protein sgk

1999 • 728 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1999 • 555 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

1993 • 537 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

sgk Is an Aldosterone-induced Kinase in the Renal Collecting Duct

1999 • 452 citations

Hormone-Induced Proliferation and Differentiation of Granulosa Cells: A Coordinated Balance of the Cell Cycle Regulators Cyclin D2 and p27^Kip1

1998 • 418 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

cAMP-dependent Protein Kinase

1989 • 274 citations

Insulin-Like Growth Factor I Regulates Gonadotropin Responsiveness in the Murine Ovary

1997 • 264 citations

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

1999 • 262 citations

Hormonal Regulation of Luteinizing Hormone/Chorionic Gonadotropin Receptor mRNA in Rat Ovarian Cells during Follicular Development and Luteinization

1990 • 242 citations

Molecular mechanisms of ovulation and luteinization

1998 • 238 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

Hormonal Control of the Cell Cycle in Ovarian Cells: Proliferation Versus Differentiation

1998 • 229 citations

Differential Effects of cAMP in Neurons and Astrocytes

1999 • 222 citations

Regulation of Cytochrome P450 Aromatase Messenger Ribonucleic Acid and Activity by Steroids and Gonadotropins in Rat Granulosa Cells^*

1991 • 220 citations

Functional Interactions, Phosphorylation, and Levels of 3′,5′-Cyclic Adenosine Monophosphate-Regulatory Element Binding Protein and Steroidogenic Factor-1 Mediate Hormone-Regulated and Constitutive Expression of Aromatase in Gonadal Cells

1997 • 209 citations

G Protein-Coupled Receptor Systems Involved in Cell Growth and Oncogenesis

1995 • 196 citations

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

1998 • 191 citations

Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation

1999 • 186 citations

Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase

1993 • 180 citations

Localization of A-kinase through anchoring proteins.

1994 • 164 citations

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

2000 • 163 citations

Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein

1999 • 152 citations

Phosphoinositide 3-OH Kinase (PI3K) and PKB/Akt Delay the Onset of p53-mediated, Transcriptionally Dependent Apoptosis

1999 • 141 citations

Follicle Stimulating Hormone (FSH) Activates the p38 Mitogen-Activated Protein Kinase Pathway, Inducing Small Heat Shock Protein Phosphorylation and Cell Rounding in Immature Rat Ovarian Granulosa Cells

1998 • 133 citations

Expression of aromatase in the ovary: Down-regulation of mRNA by the ovulatory luteinizing hormone surge

1997 • 132 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

cAMP-Dependent Protein Kinase

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Cell Cycle and Hormonal Control of Nuclear-Cytoplasmic Localization of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, in Mammary Tumor Cells

1999 • 129 citations

Insulin-Like Growth Factor-I as an Amplifier of Follicle- Stimulating Hormone Action: Studies on Mechanism(s) and Site(s) of Action in Cultured Rat Granulosa Cells*

1988 • 124 citations

Identification of a cyclic adenosine 3',5'-monophosphate-response element in the rat aromatase promoter that is required for transcriptional activation in rat granulosa cells and R2C leydig cells.

1994 • 124 citations

Follicle Stimulating Hormone-Regulated Expression of Serum/Glucocorticoid-Inducible Kinase in Rat Ovarian Granulosa Cells: A Functional Role for the Sp1 Family in Promoter Activity

1997 • 123 citations

Gonadotropins induce rapid phosphorylation of the 3',5'-cyclic adenosine monophosphate response element binding protein in ovarian granulosa cells.

1996 • 117 citations

Tyrosine kinase inhibitor AG18 arrests follicle-stimulating hormone-induced granulosa cell differentiation: use of reverse transcriptase-polymerase chain reaction assay for multiple messenger ribonucleic acids.

1994 • 116 citations

Regulation of the a Inhibin Gene by Cyclic Adenosine 3′,5′-Monophosphate after Transfection into Rat Granulosa Cells

1991 • 115 citations

Functional and Subcellular Changes in the A-Kinase-Signaling Pathway: Relation to Aromatase and Sgk Expression during the Transition of Granulosa Cells to Luteal Cells

1999 • 107 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

Activation of Cyclic AMP-Dependent Kinase Is Required but May Not Be Sufficient To Mimic Cyclic AMP-Dependent DNA Synthesis and Thyroglobulin Expression in Dog Thyroid Cells

1997 • 88 citations

Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription

1998 • 83 citations

Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15 (23):6541-6551

1997 • 76 citations

Identification and Characterization of Potential Effector Molecules of the Ras-related GTPase Rap2

1999 • 76 citations

Differential Effects of Cyclic Adenosine 3′,5′-Monophosphate on p70 Ribosomal S6 Kinase¹

1998 • 72 citations

Expression and Localization of Serum/Glucocorticoid-Induced Kinase in the Rat Ovary: Relation to Follicular Growth and Differentiation1

2000 • 71 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Gonadotropins Regulate Inducible Cyclic Adenosine 3′,5′-Monophosphate Early Repressor in the Rat Ovary: Implications for Inhibin α Subunit Gene Expression

1998 • 62 citations

A Role of Insulin-Like Growth Factor I in Luteinizing Hormone Receptor Expression in Granulosa Cells¹

1999 • 53 citations

Mitogen-Activated Protein Kinase and Protein Kinase A Signaling Pathways Stimulate Cholecystokinin Transcription via Activation of Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein

1999 • 49 citations

Ovarian expression of cellular Ki-ras p21 varies with physiological status.

1992 • 44 citations

A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth Factor-Induced CREB (cAMP-Responsive Element-Binding Protein) Activation, Uncoupled from Serine 133 Phosphorylation in NIH 3T3 Cells

1999 • 40 citations

Regulation of Expression of A-Kinase Anchoring Proteins in Rat Granulosa Cells1

1998 • 23 citations