Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*

1996 • 1,078 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

1997 • 654 citations

Agrin Acts via a MuSK Receptor Complex

1996 • 653 citations

Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice

1995 • 634 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis.

1996 • 601 citations

Oncoprotein Networks

1997 • 532 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

Insulin signal transduction through protein kinase cascades.

1998 • 364 citations

Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

1997 • 351 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1991 • 344 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.

1988 • 236 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

How is myogenesis initiated in the embryo?

1996 • 231 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

An essential role of phosphatidylinositol 3-kinase in myogenic differentiation

1998 • 126 citations

Ras - a versatile cellular switch

1998 • 100 citations

Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo

1997 • 50 citations