Cell Type-specific Regulation of B-Raf Kinase by cAMP and 14-3-3 Proteins

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Assay for nanogram quantities of DNA in cellular homogenates

1979 • 923 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1999 • 580 citations

The ins and outs of Raf kinases

1994 • 537 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1998 • 471 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

2000 • 285 citations

Isotype-Specific Functions of Raf Kinases

1999 • 259 citations

14-3-3 proteins on the MAP

1995 • 255 citations

Differential Effects of cAMP in Neurons and Astrocytes

1999 • 222 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity

1998 • 219 citations

14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner

1995 • 217 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

Bcr and Raf form a complex in vivo via 14-3-3 proteins.

1995 • 201 citations

Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

1995 • 200 citations

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

1994 • 175 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

1995 • 161 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Activation of Brain B-Raf Protein Kinase by Rap1B Small GTP-binding Protein

1996 • 151 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Suppression of Ras-Induced Transformation of NIH 3T3 Cells by Activated Gα _S

1994 • 139 citations

14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

1998 • 138 citations

Multiple isoforms of a protein kinase C inhibitor (KCIP‐1/14‐3‐3) from sheep brain

1992 • 135 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

The Cyclic Adenosine Monophosphate-dependent Protein Kinase (PKA) Is Required for the Sustained Activation of Mitogen-activated Kinases and Gene Expression by Nerve Growth Factor

1998 • 132 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain

1997 • 127 citations

14-3-3 proteins: biological function and domain structure

1995 • 125 citations

Mapping of the C5a receptor signal transduction network in human neutrophils.

1994 • 124 citations

Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway

1999 • 121 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity by Adenovirus-mediated Gene Transfer and Its Effect on Insulin Action

1998 • 119 citations

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.

1990 • 112 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Cyclic-GMP-Dependent Protein Kinase Inhibits the Ras/Mitogen-Activated Protein Kinase Pathway

1998 • 109 citations

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

1991 • 102 citations

Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf

1998 • 102 citations

Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins

1995 • 100 citations

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

1997 • 100 citations

Parathyroid Hormone Activates Mitogen-activated Protein Kinase via a cAMP-mediated Pathway Independent of Ras

1997 • 90 citations

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

1996 • 88 citations

95-Kilodalton B-Raf Serine/Threonine Kinase: Identification of the Protein and Its Major Autophosphorylation Site

1992 • 83 citations

Regulation of the MAP kinase cascade in PC12 cells: B‐Raf activates MEK‐1 (MAP kinase or ERK kinase) and is inhibited by cAMP

1995 • 82 citations

Analysis of the Gs/Mitogen-activated Protein Kinase Pathway in Mutant S49 Cells

1998 • 82 citations

14-3-3 Proteins: Hot numbers in signal transduction

1995 • 82 citations

Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.

1996 • 74 citations

Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf.

1994 • 73 citations

Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.

1995 • 70 citations

Interactions of c-Raf-1 with phosphatidylserine and 14-3-3

1999 • 68 citations

Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1.

1995 • 68 citations

Regulation of Interaction of ras p21 with RalGDS and Raf-1 by Cyclic AMP-dependent Protein Kinase

1996 • 67 citations

Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

1994 • 66 citations

Activity of Rap1 Is Regulated by Bombesin, Cell Adhesion, and Cell Density in NIH3T3 Fibroblasts

1998 • 63 citations

Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.

1990 • 62 citations

Identification of Raf‐1 Ser⁶²¹ kinase activity from NIH 3T3 cells as AMP‐activated protein kinase

1997 • 61 citations

Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.

1994 • 55 citations

Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase

2000 • 54 citations

Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation

2000 • 48 citations

Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines.

1995 • 45 citations

In search of a function for the Ras‐like GTPase Rap1

1997 • 45 citations

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

1995 • 42 citations

Nerve Growth Factor-stimulated B-Raf Catalytic Activity Is Refractory to Inhibition by cAMP-dependent Protein Kinase

1999 • 36 citations

Using a Eukaryotic GST Fusion Vector for Proteins Difficult to Express in E. coli

1997 • 35 citations

Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells

2000 • 21 citations

The Product of the Primary Response Gene BRF1 Inhibits the Interaction between 14-3-3 Proteins and cRaf-1 in the Yeast Trihybrid System

1999 • 12 citations