cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation

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2005 • 8,820 citations

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1990 • 5,528 citations

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1986 • 5,148 citations

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1974 • 4,213 citations

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1992 • 2,581 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Tumor Angiogenesis

1985 • 1,038 citations

Regulators of Angiogenesis

1991 • 959 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

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1977 • 497 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Human Vascular Permeability Factor

1989 • 282 citations

Fibroblast growth factors

1987 • 273 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

1995 • 231 citations

The 16K Fragment of Prolactin Specifically Inhibits Basal or Fibroblast Growth Factor Stimulated Growth of Capillary Endothelial Cells

1991 • 217 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor

1984 • 123 citations

Cell cycle-dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E1

1985 • 115 citations

Inhibition of proliferation, but not of Ca2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells

1992 • 108 citations

The effects of β‐adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium

1994 • 90 citations

Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways.

1995 • 67 citations

Forskolin, phosphodiesterase inhibitors, and cyclic AMP analogs inhibit proliferation of cultured bovine aortic endothelial cells

1986 • 58 citations

A Key Role for Protein Kinase A in Homologous Desensitization of the β2-Adrenergic Receptor Pathway in S49 Lymphoma Cells

1996 • 51 citations

Voltage‐dependent currents and modulation of calcium channel expression in zona fasciculata cells from rat adrenal gland.

1995 • 43 citations

IL-4, but not tumor necrosis factor-alpha, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway.

1993 • 36 citations

Inhibition of the production of platelet activating factor and of leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate.

1995 • 33 citations

Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells

1995 • 32 citations

Functional effects of long‐term activation on human β₂‐ and β₃‐adrenoceptor signalling

1995 • 31 citations

Adrenergic receptors coupled to adenylate cyclase in human cerebromicrovascular endothelium

1992 • 22 citations

Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.

1995 • 22 citations

Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression.

1992 • 15 citations

Prostaglandin‐stimulated second messenger signaling in bone‐derived endothelial cells is dependent on confluency in culture

1994 • 11 citations

Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro

1994 • 9 citations

Effects of adrenochrome and epinephrine on human arterial endothelial cells in vitro.

1995 • 7 citations

Protamine Sulfate Inhibition of Serum-Induced Mitogenic Responses: Differential Effects on Normal and Neoplastic Cells<xref ref-type="fn" rid="FN2">2</xref>

1984 • 6 citations