Activation of the CAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

Negative selection of lymphocytes

1994 • 810 citations

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

1998 • 656 citations

Cyclic nucleotide-dependent protein kinases

1991 • 487 citations

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

1998 • 349 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

1997 • 336 citations

Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse

1998 • 329 citations

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1995 • 317 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

From Epinephrine to Cyclic AMP

1988 • 255 citations

Novel (Rp)-cAMPS Analogs as Tools for Inhibition of cAMP-kinase in Cell Culture

1995 • 236 citations

Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry

1991 • 226 citations

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

1995 • 209 citations

Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex

1994 • 200 citations

mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response

1998 • 191 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3‘,5‘-cyclic adenosine monophosphate on cell replication in human T lymphocytes.

1992 • 186 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.

1994 • 163 citations

Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells.

1996 • 155 citations

Mcl-1 in Transgenic Mice Promotes Survival in a Spectrum of Hematopoietic Cell Types and Immortalization in the Myeloid Lineage

1998 • 151 citations

B cell development in the bone marrow.

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Noradrenergic and peptidergic innervation of the mouse femur bone marrow

1996 • 124 citations

The cAMP-dependent protein kinases and cAMP signal transduction.

1994 • 120 citations

Inhibition of glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3‘,5‘-phosphorothioate.

1983 • 111 citations

Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes.

1996 • 103 citations

Bone marrow innervation regulates cellular retention in the murine haemopoietic system

1997 • 102 citations

Isolation and characterization of human hematopoietic progenitor cells: an effective method for positive selection of CD34+ cells.

1992 • 89 citations

A new method for detachment of Dynabeads from positively selected B lymphocytes

1992 • 87 citations

Bcl-x protects primary B cells against Fas-mediated apoptosis.

1997 • 81 citations

Interleukin-13 in Combination With CD40 Ligand Potently Inhibits Apoptosis in Human B Lymphocytes: Upregulation of Bcl-xL and Mcl-1

1997 • 81 citations

Selective Activation of cAMP-dependent Protein Kinase Type I Inhibits Rat Natural Killer Cell Cytotoxicity

1997 • 77 citations

Apoptosis during B lymphopoiesis in mouse bone marrow.

1997 • 77 citations

The Role of the Sympathetic Nervous System in the Modulation of Immune Responses

1997 • 75 citations

Cyclic AMP‐mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha‐ras protooncogenes

1987 • 68 citations

Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway.

1996 • 58 citations

Inhibition of human B cell activation by diterpine forskolin: interference with B cell growth factor-induced G1 to S transition of the B cell cycle.

1984 • 57 citations

A molecular analysis of PGE receptor (EP) expression on normal and transformed B lymphocytes: Coexpression of EP1, EP2, EP3β and EP4

1996 • 57 citations

Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes.

1996 • 53 citations

The adenylyl cyclase family

1991 • 50 citations

Cyclic AMP‐dependent protein kinase (cAK) in human B cells: co‐localization of type I cAK (RIα₂C₂) with the antigen receptor during anti‐immunoglobulin‐induced B cell activation

1996 • 46 citations

No Neuronal Regulation of Murine Bone Marrow Function

1998 • 43 citations

The Apoptosis and Proliferation of SAC-Activated B Cells by IL-10 Are Associated with Changes in Bcl-2, Bcl-xL, and Mcl-1 Expression

1997 • 39 citations

Involvement of cAMP in CD3 T cell receptor complex‐ and CD2‐mediated apoptosis of human thymocytes

1995 • 30 citations

Stromal cells regulate bcl-2 and bax expression in pro-B cells.

1996 • 30 citations

Cell signalling : Experimental strategies

1991 • 29 citations

Bcl-2 expression inhibits prostaglandin E2-mediated apoptosis in B cell lymphomas.

1996 • 27 citations

Characterization and Regulation of Prostaglandin E2 Receptors on Normal and Malignant Murine B Lymphocytes

1995 • 25 citations

Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.

1994 • 17 citations