On the mitogenic properties of Rap1b: cAMP-induced G ₁ /S entry requires activated and phosphorylated Rap1b

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1992 • 535 citations

The cyclic AMP-mediated stimulation of cell proliferation

1989 • 464 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes

1987 • 244 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

2001 • 155 citations

Cyclic AMP: a mitogenic signal for Swiss 3T3 cells.

1981 • 150 citations

Mitogenic and oncogenic properties of the small G protein Rap1b

1998 • 140 citations

Suppression of Ras-Induced Transformation of NIH 3T3 Cells by Activated Gα _S

1994 • 139 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A

2001 • 130 citations

Activation of Mitogen-activated Protein Kinase by the A2A-adenosine Receptor via a rap1-dependent and via a p21 -dependent Pathway

1999 • 121 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N)

1997 • 106 citations

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.

1990 • 105 citations

Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems

2000 • 105 citations

Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases

1994 • 104 citations

Activation of Cyclic AMP-Dependent Kinase Is Required but May Not Be Sufficient To Mimic Cyclic AMP-Dependent DNA Synthesis and Thyroglobulin Expression in Dog Thyroid Cells

1997 • 88 citations

Measurement of GTP-bound Ras-like GTPases by activation-specific probes

2001 • 85 citations

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

1999 • 84 citations

Differential Effects of Protein Kinase A on Ras Effector Pathways

1998 • 73 citations

Molecular events involved in differentiation of thyroid follicular cells

1998 • 70 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Mutational analysis of the cAMP-dependent protein kinase-mediated phosphorylation site of Rap1b.

1993 • 65 citations

Multiple Ras Downstream Pathways Mediate Functional Repression of the Homeobox Gene Product TTF-1

2000 • 64 citations

Cyclic AMP activates Ras

2000 • 62 citations

Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

1995 • 60 citations

Effect of Phosphorylation on Activities of Rap1A to Interact with Raf-1 and to Suppress Ras-dependent Raf-1 Activation

1999 • 59 citations

Activation of the Small G Protein Rap1 in Dog Thyroid Cells by Both cAMP-Dependent and -Independent Pathways

2000 • 58 citations

Structures and functions of the Krev-1 transformation suppressor gene and its relatives

1993 • 57 citations

Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells

1999 • 54 citations

Insulin, growth factors, and cAMP

1996 • 43 citations

Ras inhibits thyroglobulin expression but not cyclic adenosine monophosphate-mediated signaling in Wistar rat thyrocytes.

1996 • 35 citations

rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21

1995 • 27 citations