Rap1 signalling: adhering to new models

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

2001 • 556 citations

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

2000 • 480 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs

2000 • 390 citations

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY

1995 • 361 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis

1997 • 353 citations

Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase

2000 • 340 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor

1996 • 328 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

2000 • 259 citations

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

2000 • 239 citations

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi

1999 • 227 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

1999 • 204 citations

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

2000 • 193 citations

The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for Degradation

1999 • 188 citations

Rap1 GTPase-activating Protein SPA-1 Negatively Regulates Cell Adhesion

1999 • 175 citations

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf

2000 • 174 citations

Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex

1994 • 167 citations

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

2000 • 163 citations

cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons

2001 • 158 citations

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

2000 • 156 citations

Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein

1999 • 152 citations

Activation of Brain B-Raf Protein Kinase by Rap1B Small GTP-binding Protein

1996 • 151 citations

The Rap1 GTPase functions as a regulator of morphogenesis invivo

1999 • 141 citations

Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL

2000 • 141 citations

Mitogenic and oncogenic properties of the small G protein Rap1b

1998 • 140 citations

CalDAG-GEFIII Activation of Ras, R-Ras, and Rap1

2000 • 140 citations

Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily

1999 • 132 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A

2001 • 130 citations

Human SPA-1 Gene Product Selectively Expressed in Lymphoid Tissues Is a Specific GTPase-activating Protein for Rap1 and Rap2

1997 • 128 citations

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

1999 • 126 citations

Activation of R-Ras by Ras-Guanine Nucleotide-releasing Factor

1997 • 126 citations

Activation of C3G Guanine Nucleotide Exchange Factor for Rap1 by Phosphorylation of Tyrosine 504

1999 • 124 citations

The Drosophila Roughened mutation: Activation of a rap homolog disrupts eye development and interferes with cell determination

1991 • 123 citations

The Adapter Protein Crkl Links Cbl to C3G after Integrin Ligation and Enhances Cell Migration

1999 • 114 citations

Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade

2000 • 113 citations

The Ras Target AF-6 is a Substrate of the Fam Deubiquitinating Enzyme

1998 • 111 citations

Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective

2001 • 106 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

nRap GEP: A Novel Neural GDP/GTP Exchange Protein for Rap1 Small G Protein That Interacts with Synaptic Scaffolding Molecule (S-SCAM)

1999 • 105 citations

Cell Type-specific Regulation of B-Raf Kinase by cAMP and 14-3-3 Proteins

2000 • 101 citations

Sequential Regulation of the Small GTPase Rap1 in Human Platelets

2000 • 100 citations

p130Cas Regulates the Activity of AND-34, a Novel Ral, Rap1, and R-Ras Guanine Nucleotide Exchange Factor

2000 • 97 citations

Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.

1991 • 96 citations

The Small M_rRas-like GTPase Rap1 and the Phospholipase C Pathway Act to Regulate Phagocytosis inDictyostelium discoideum

1999 • 94 citations

Lipopolysaccharide-Induced Activation of β2-Integrin Function in Macrophages Requires Irak Kinase Activity, p38 Mitogen- Activated Protein Kinase, and the Rap1 GTPase

2001 • 94 citations

Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes

1998 • 92 citations

Functional Interaction between Gαz and Rap1GAP Suggests a Novel Form of Cellular Cross-talk

1999 • 92 citations

Activation of the Rap1 GTPase by the B Cell Antigen Receptor

1998 • 88 citations

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

1999 • 87 citations

Rap1 Is Activated by Erythropoietin or Interleukin-3 and Is Involved in Regulation of β1 Integrin-mediated Hematopoietic Cell Adhesion

2001 • 85 citations

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

1999 • 84 citations

CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

2000 • 81 citations

Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559

1992 • 78 citations

H-Ras Signals to Cytoskeletal Machinery in Induction of Integrin-Mediated Adhesion of T Cells

1999 • 77 citations

A Candida albicans RAS-related gene (CaRSRl) is involved in budding, cell morphogenesis and hypha development

1997 • 77 citations

Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site

1999 • 76 citations

Divergent Roles for Ras and Rap in the Activation of p38 Mitogen-activated Protein Kinase by Interleukin-1

2000 • 76 citations

cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating Ser-43 of Raf-1 in the MAPK/ERK pathway

2000 • 74 citations

Crk Activation of JNK via C3G and R-Ras

2000 • 71 citations

Activation of the Rap1 Guanine Nucleotide Exchange Gene,CalDAG-GEF I, in BXH-2 Murine Myeloid Leukemia

2001 • 68 citations

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

1997 • 67 citations

In VivoInteraction of AF-6 with Activated Ras and ZO-1

1999 • 63 citations

Activity of Rap1 Is Regulated by Bombesin, Cell Adhesion, and Cell Density in NIH3T3 Fibroblasts

1998 • 63 citations

Identification of a Novel β-Catenin-Interacting Protein

2000 • 62 citations

The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein

1991 • 60 citations

Activation of the Small G Protein Rap1 in Dog Thyroid Cells by Both cAMP-Dependent and -Independent Pathways

2000 • 58 citations

Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase

2000 • 54 citations

Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1

1999 • 54 citations

Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1

1999 • 43 citations

Mutational Analysis of the Role of Rap1 in Regulating Cytoskeletal Function inDictyostelium

1997 • 43 citations

The Association of CRKII with C3G Can be Regulated by Integrins and Defines a Novel Means to Regulate the Mitogen-activated Protein Kinases

2000 • 42 citations

β-Adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion

1998 • 42 citations

GTK, a Src-related Tyrosine Kinase, Induces Nerve Growth Factor-independent Neurite Outgrowth in PC12 Cells through Activation of the Rap1 Pathway

2000 • 40 citations

A role for p21ras/MAP kinase in TCR-mediated activation of LFA-1.

1998 • 38 citations

Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro.

1992 • 36 citations

Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1

1997 • 35 citations

Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology

1998 • 34 citations

Insulin and Epidermal Growth Factor Stimulate a Conformational Change in Rap1 and Dissociation of the CrkII-C3G Complex

1997 • 33 citations

NGF-Dependent Neurite Outgrowth in PC12 Cells Overexpressing the Src Homology 2-Domain Protein Shb Requires Activation of the Rap1 Pathway

2000 • 32 citations

Cutting Edge: A Role for p21ras/MAP Kinase in TCR-Mediated Activation of LFA-1

1998 • 26 citations

Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae.

1992 • 24 citations