Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

2005 • 4,388 citations

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

2006 • 2,414 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

2000 • 1,416 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

2002 • 990 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1997 • 779 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas

2000 • 513 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

2006 • 381 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

2006 • 331 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Developing a new paradigm for thymus organogenesis

2004 • 242 citations

The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein.

1996 • 234 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus

2002 • 195 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

2000 • 162 citations

Gene defect behind APECED: a new clue to autoimmunity

1998 • 154 citations

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

1985 • 126 citations

Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

2006 • 86 citations

IPF1, a homeodomain protein with a dual function in pancreas development.

1995 • 84 citations

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.

1999 • 83 citations

Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

2006 • 79 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer

1999 • 62 citations

Transgenic Expression of Cyclin D1 in Thymic Epithelial Precursors Promotes Epithelial and T Cell Development

2000 • 62 citations

Thymic vasculature: organizer of the medullary epithelial compartment?

2000 • 61 citations

Cervical Thymus in the Mouse

2006 • 60 citations

The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development

2006 • 51 citations

Cell-Specific Expression of Glucose-Dependent-Insulinotropic Polypeptide Is Regulated by the Transcription Factor PDX-1

2004 • 50 citations

Insulin stimulates pancreatic–duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic β cells

1999 • 45 citations

An Organized Medullary Epithelial Structure in the Normal Thymus Expresses Molecules of Respiratory Epithelium and Resembles the Epithelial Thymic Rudiment of Nude Mice

2005 • 39 citations

Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium

2005 • 34 citations

A novel cytokine-responsive cell surface glycoprotein defines a subset of medullary thymic epithelium in situ.

1993 • 32 citations