Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Glutamate receptor ion channels

2005 • 3,667 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1999 • 1,479 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

Extracellular Calcium Sensing and Extracellular Calcium Signaling

2001 • 1,383 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

2000 • 1,201 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

2000 • 1,197 citations

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

Homer: a protein that selectively binds metabotropic glutamate receptors

1997 • 1,058 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

G Protein-coupled Receptors

1998 • 1,033 citations

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

1999 • 1,024 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin

1999 • 980 citations

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

1994 • 884 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1998 • 855 citations

Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors

1998 • 852 citations

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

1994 • 730 citations

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1999 • 724 citations

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1993 • 724 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

A Novel Family of Putative Pheromone Receptors in Mammals with a Topographically Organized and Sexually Dimorphic Distribution

1997 • 694 citations

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

1997 • 631 citations

Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins

1998 • 630 citations

A New Multigene Family of Putative Pheromone Receptors

1997 • 612 citations

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice

1994 • 607 citations

How the protease thrombin talks to cells

1999 • 574 citations

Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins

1996 • 539 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes

1996 • 537 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer

1996 • 512 citations

Dimerization of the δ Opioid Receptor:

1997 • 479 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1994 • 466 citations

Postsynaptic organisation and regulation of excitatory synapses

2000 • 452 citations

Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain

1997 • 437 citations

THE ‘ABC’ OF GABA RECEPTORS: A BRIEF REVIEW

1999 • 423 citations

mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination

2000 • 412 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

2001 • 397 citations

Metabotropic Glutamate Receptor Subtypes 1 and 5 Are Activators of Extracellular Signal-Regulated Kinase Signaling Required for Inflammatory Pain in Mice

2001 • 376 citations

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

1992 • 367 citations

Synergistic Release of Ca2+ from IP3-Sensitive Stores Evoked by Synaptic Activation of mGluRs Paired with Backpropagating Action Potentials

1999 • 334 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 329 citations

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

1999 • 324 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

Molecular determinants of metabotropic glutamate receptor signaling

2001 • 307 citations

Functional coupling between ryanodine receptors and L-type calcium channels in neurons

1996 • 304 citations

High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus

1995 • 292 citations

Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors

1996 • 289 citations

Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons

1998 • 285 citations

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

2000 • 278 citations

Novel Members of the Vesl/Homer Family of PDZ Proteins That Bind Metabotropic Glutamate Receptors

1998 • 277 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

2000 • 263 citations

SAP90 Binds and Clusters Kainate Receptors Causing Incomplete Desensitization

1998 • 261 citations

Emerging roles for RGS proteins in cell signalling

1999 • 255 citations

Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.

1994 • 246 citations

Intracellular Ca2+ activates phospholipase C

1988 • 233 citations

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

1998 • 229 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation

2000 • 224 citations

Structural Basis for a Ca ²⁺ -Sensing Function of the Metabotropic Glutamate Receptors

1998 • 216 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 213 citations

Homer 1b Regulates the Trafficking of Group I Metabotropic Glutamate Receptors

1999 • 211 citations

Cloning and Expression of Rat Metabotropic Glutamate Receptor 8 Reveals a Distinct Pharmacological Profile

1997 • 209 citations

Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding

1999 • 209 citations

Regulator of G protein signaling proteins: novel multifunctional drug targets.

2001 • 205 citations

Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation

2000 • 204 citations

Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems

1999 • 198 citations

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1994 • 197 citations

Homer Proteins Regulate Coupling of Group I Metabotropic Glutamate Receptors to N-Type Calcium and M-Type Potassium Channels

2000 • 193 citations

Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

2001 • 188 citations

Role of Protein Kinase C Phosphorylation in Rapid Desensitization of Metabotropic Glutamate Receptor 5

1998 • 187 citations

Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

2000 • 184 citations

Identification of the Cysteine Residues in the Amino-terminal Extracellular Domain of the Human Ca2+ Receptor Critical for Dimerization

1999 • 184 citations

The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain

1999 • 183 citations

Metabotropic Glutamate 1α and Adenosine A1 Receptors Assemble into Functionally Interacting Complexes

2001 • 179 citations

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

1995 • 175 citations

G-protein-independent signaling mediated by metabotropic glutamate receptors

1999 • 174 citations

Differential Subcellular Localization of mGluR1a and mGluR5 in the Rat and Monkey Substantia Nigra

2001 • 171 citations

BAY36-7620: A Potent Non-Competitive mGlu1 Receptor Antagonist with Inverse Agonist Activity.

2001 • 166 citations

Role of the Second and Third Intracellular Loops of Metabotropic Glutamate Receptors in Mediating Dual Signal Transduction Activation

1998 • 161 citations

The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

1996 • 155 citations

New perspectives for the development of selective metabotropic glutamate receptor ligands

1999 • 150 citations

Positive and Negative Coupling of the Metabotropic Glutamate Receptors to a G Protein–activated K+ Channel, GIRK, in Xenopus Oocytes

1997 • 148 citations

Expression and Purification of the Extracellular Ligand Binding Region of Metabotropic Glutamate Receptor Subtype 1

1998 • 147 citations

RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors

1998 • 146 citations

Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors

1999 • 144 citations

Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.

1993 • 141 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 140 citations

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

1996 • 139 citations

The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

1997 • 138 citations

Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C

2001 • 137 citations

The G‐protein‐coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1

2000 • 136 citations

Phosphorylation and Calmodulin Binding of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) Are Antagonistic in Vitro

1997 • 134 citations

Activation of the G Protein Gq/11 Through Tyrosine Phosphorylation of the α Subunit

1997 • 134 citations

Switch from Facilitation to Inhibition of Excitatory Synaptic Transmission by Group I mGluR Desensitization

1998 • 133 citations

Binding of Calmodulin to the D2-Dopamine Receptor Reduces Receptor Signaling by Arresting the G Protein Activation Switch

2000 • 132 citations

Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors?

1999 • 131 citations

NMDA Receptor Stimulation and Brain-Derived Neurotrophic Factor Upregulate Homer 1a mRNA via the Mitogen-Activated Protein Kinase Cascade in Cultured Cerebellar Granule Cells

2001 • 131 citations

Covalent and Noncovalent Interactions Mediate Metabotropic Glutamate Receptor mGlu₅Dimerization

2001 • 129 citations

Calmodulin Binding to G Protein-coupling Domain of Opioid Receptors

1999 • 128 citations

Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8

1998 • 127 citations

Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering

1999 • 127 citations

Ca²⁺ Requirement for High-Affinity γ-Aminobutyric Acid (GABA) Binding at GABA_B Receptors: Involvement of Serine 269 of the GABA_BR1 Subunit

2000 • 127 citations

Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568.

1998 • 123 citations

Cryptic Dimer Interface and Domain Organization of the Extracellular Region of Metabotropic Glutamate Receptor Subtype 1

2000 • 123 citations

[Ca2+] Oscillation Frequency Regulates Agonist-stimulated NF-κB Transcriptional Activity

1999 • 122 citations

Expression of RGS2 Alters the Coupling of Metabotropic Glutamate Receptor 1a to M-Type K+ and N-Type Ca2+ Channels

1999 • 121 citations

G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death

2000 • 121 citations

G-protein-independent signaling by G-protein-coupled receptors

2000 • 120 citations

Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons

1996 • 118 citations

Dimerization of the Calcium-sensing Receptor Occurs within the Extracellular Domain and Is Eliminated by Cys → Ser Mutations at Cys101 and Cys236

1999 • 115 citations

Domains determining ligand specificity for Ca2+ receptors.

1999 • 115 citations

Metabotropic Glutamate Receptor mGluR5 in Astrocytes: Pharmacological Properties and Agonist Regulation

1997 • 114 citations

Homer-1c/Vesl-1L Modulates the Cell Surface Targeting of Metabotropic Glutamate Receptor Type 1α: Evidence for an Anchoring Function

2000 • 114 citations

Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

1998 • 113 citations

Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5

1995 • 111 citations

Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: Selective desensitization of the inositol trisphosphate/Ca ²⁺ pathway by phosphorylation of the receptor-G protein-coupling domain

2000 • 110 citations

A Novel Splice Variant of a Metabotropic Glutamate Receptor, Human mGluR7b

1997 • 109 citations

The N-Terminal Domain of γ-Aminobutyric Acid_BReceptors Is Sufficient to Specify Agonist and Antagonist Binding

1999 • 107 citations

A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1α metabotropic glutamate receptors

1997 • 107 citations

A Variant of Metabotropic Glutamate Receptor Subtype 5: An Evolutionally Conserved Insertion with No Termination Codon

1993 • 103 citations

Cupidin, an Isoform of Homer/Vesl, Interacts with the Actin Cytoskeleton and Activated Rho Family Small GTPases and Is Expressed in Developing Mouse Cerebellar Granule Cells

1999 • 103 citations

Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways

2001 • 101 citations

Co-expression of metabotropic glutamate receptor type 1α with Homer-1a/Vesl-1S increases the cell surface expression of the receptor

1999 • 101 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations

1999 • 99 citations

Rapid Desensitization of the Metabotropic Glutamate Receptor that Facilitates Glutamate Release in Rat Cerebrocortical Nerve Terminals

1994 • 99 citations

Human Ca2+ Receptor Cysteine-rich Domain

2000 • 97 citations

Mutational analysis of the cysteines in the extracellular domain of the human Ca²⁺ receptor: effects on cell surface expression, dimerization and signal transduction

1998 • 97 citations

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

1993 • 96 citations

Phosphorylation of Mitogen‐Activated Protein Kinase in Cultured Rat Cortical Glia by Stimulation of Metabotropic Glutamate Receptors

1998 • 96 citations

In VitroBinding Characteristics of a New Selective Group II Metabotropic Glutamate Receptor Radioligand, [³H]LY354740, in Rat Brain

1998 • 96 citations

Agonist‐induced internalization of the metabotropic glutamate receptor 1a is arrestin‐ and dynamin‐dependent

2001 • 89 citations

Desensitization of Metabotropic Glutamate Receptors in Neuronal Cultures

1991 • 87 citations

Metabotropic Glutamate Receptor Subtype mGluR1α Stimulates the Secretion of the Amyloid β‐Protein Precursor Ectodomain

1997 • 87 citations

Metabotropic Excitatory Amino Acid Receptor Activation Stimulates Phospholipase D in Hippocampal Slices

1992 • 87 citations

Calcium sensing properties of the GABAB receptor

1999 • 84 citations

Role of Ca²⁺Stores in Metabotropicl-Glutamate Receptor-Mediated Supralinear Ca²⁺Signaling in Rat Hippocampal Neurons

2000 • 82 citations

A Cluster of Basic Residues in the Carboxyl-terminal Tail of the Short Metabotropic Glutamate Receptor 1 Variants Impairs Their Coupling to Phospholipase C

1998 • 81 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 81 citations

Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization

2000 • 81 citations

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

1996 • 78 citations

Diversity of Calcium Signaling by Metabotropic Glutamate Receptors

1998 • 77 citations

Characterization of the Dimerization of Metabotropic Glutamate Receptors Using an N‐Terminal Truncation of mGluR1α

1999 • 77 citations

Ligand Binding to the Amino-terminal Domain of the mGluR4 Subtype of Metabotropic Glutamate Receptor

1999 • 77 citations

Metabotropic G-protein-coupled glutamate receptors as therapeutic targets

1999 • 76 citations

The Expression of Two Splice Variants of Metabotropic Glutamate Receptor Subtype 5 in the Rat Brain and Neuronal Cells During Development

1995 • 76 citations

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

1995 • 76 citations

The G Protein-Coupling Profile of Metabotropic Glutamate Receptors, as Determined with Exogenous G Proteins, Is Independent of Their Ligand Recognition Domain

1998 • 75 citations

Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8

1999 • 72 citations

Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.

1995 • 71 citations

Molecular Cloning and the Functional Expression of Two Isoforms of Human Metabotropic Glutamate Receptor Subtype 5

1994 • 71 citations

Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.

1996 • 71 citations

Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat

1994 • 69 citations

Spatial-Temporal Patterning of Metabotropic Glutamate Receptor-mediated Inositol 1,4,5-Triphosphate, Calcium, and Protein Kinase C Oscillations

2001 • 69 citations

The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo

2001 • 67 citations

Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

1996 • 67 citations

Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing

2000 • 65 citations

Rat group I Metabotropic Glutamate Receptors Inhibit Neuronal Ca²⁺Channels via Multiple Signal Transduction Pathways in HEK 293 Cells

1998 • 62 citations

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

1995 • 61 citations

Characterization of [³H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections

2000 • 61 citations

Interactions of the C Terminus of Metabotropic Glutamate Receptor Type 1α with Rat Brain Proteins

1999 • 59 citations

Functional Importance of the Ala116–Pro136 Region in the Calcium-sensing Receptor

2000 • 59 citations

Molecular Determinants of Metabotropic Glutamate Receptor 1B Trafficking

2001 • 58 citations

Molecular characterization and localization of human metabotropic glutamate receptor type 3

1996 • 58 citations

Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1α by protein kinase C in permanently transfected BHK cells

1995 • 57 citations

Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells

1997 • 56 citations

Effects of varying the expression level of recombinant human mGlu1α receptors on the pharmacological properties of agonists and antagonists

1999 • 55 citations

Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor

1998 • 54 citations

Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.

1993 • 54 citations

Leucine/isoleucine/valine-binding protein contracts upon binding of ligand

1993 • 54 citations

HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor

1996 • 53 citations

Reassessment of the Ca2+ Sensing Property of a Type I Metabotropic Glutamate Receptor by Simultaneous Measurement of Inositol 1,4,5-Trisphosphate and Ca2+ in Single Cells

2001 • 50 citations

A modulatory effect of extracellular Ca2+ on type 1α metabotropic glutamate receptor-mediated signalling

1998 • 50 citations

Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype

1997 • 49 citations

Cloning and Characterization of a Metabotropic Glutamate Receptor, mGluR4b

1997 • 48 citations

Cloning of novel splice variants of mouse mGluR1

1999 • 48 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

1995 • 48 citations

Group I Metabotropic Glutamate Receptors Mediate Phospholipase D Stimulation in Rat Cultured Astrocytes

1999 • 48 citations

PKC phosphorylation of a conserved serine residue in the C‐terminus of group III metabotropic glutamate receptors inhibits calmodulin binding

2001 • 47 citations

Homology Modeling of Metabotropic Glutamate Receptors. (mGluRs) Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists

1996 • 47 citations

Group I mGluRs Coupled to G Proteins Are Regulated by Tyrosine Kinase in Dopamine Neurons of the Rat Midbrain

2001 • 44 citations

Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor

1999 • 43 citations

Pharmacological characterization of type 1α metabotropic glutamate receptor‐stimulated [³⁵S]‐GTPγS binding

1997 • 39 citations

Glutamate‐Stimulated Activation of DNA Synthesis via Mitogen‐Activated Protein Kinase in Primary Astrocytes

2000 • 37 citations

Characterization of (2S,2′R,3′R)‐2‐(2′,3′‐[³H]‐Dicarboxycyclopropyl)glycine Binding in Rat Brain

1998 • 37 citations

Phorbol Esters Attenuate Glutamate‐Stimulated Inositol Phospholipid Hydrolysis in Neuronal Cultures

1988 • 36 citations

Cell type-specific differences in the coupling of recombinant mGlu1α receptors to endogenous G protein sub-populations

2001 • 36 citations

Characterization of metabotropic glutamate receptors in rat C6 glioma cells

1997 • 35 citations

The Whole Nucleotide Sequence and Chromosomal Localization of the Gene for Human Metabotropic Glutamate Receptor Subtype 6

1997 • 34 citations

Identification, cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA

1999 • 32 citations

The rat mGlu1d receptor splice variant shares functional properties with the other short isoforms of mGlu1 receptor

1997 • 31 citations

Metabotropic glutamate receptor type 1α and tubulin assemble into dynamic interacting complexes

2001 • 31 citations

Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium‐dependence of the phospholipase C response

2001 • 31 citations

Metabotropic glutamate receptor activation and intracellular cyclic ADP-ribose release Ca2+from the same store in cultured DRG neurones

1999 • 30 citations

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

1995 • 28 citations

The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity

1995 • 28 citations

The role of Arg78 in the metabotropic glutamate receptor mGlu1 for agonist binding and selectivity

2000 • 28 citations

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

1999 • 27 citations

Constraints on proper folding of the amino terminal domains of group iii metabotropic glutamate receptors

2000 • 27 citations

A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution

1997 • 27 citations

Bidirectional Regulation of Neurite Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (mGluR5) Isoforms

2001 • 26 citations

Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine versus 3, 5-dihydroxyphenylglycine.

1999 • 26 citations

Differential coupling of G‐protein‐linked receptors to Ca²⁺ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture

1999 • 26 citations

Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate

1996 • 26 citations

Inositol phospholipid metabolism in Xenopus oocytes mediated by endogenous G_o and G_i proteins

1994 • 24 citations

Expression of a novel splice variant of human mGluR1 in the cerebellum

1997 • 23 citations

Effects of Human Type 1α Metabotropic Glutamate Receptor Expression Level on Phosphoinositide and Ca²⁺ Signalling in an Inducible Cell Expression System

1998 • 23 citations

Inhibition of the Phospholipase C‐Linked Metabotropic Glutamate Receptor by 2‐Amino‐3‐Phosphonopropionate Is Dependent on Extracellular Calcium

1992 • 23 citations

Complex Involvement of Pertussis Toxin-Sensitive G Proteins in the Regulation of Type 1α Metabotropic Glutamate Receptor Signaling in Baby Hamster Kidney Cells

2000 • 23 citations

Inhibition of N-linked glycosylation of the human type 1α metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function

1999 • 22 citations

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways

1993 • 22 citations

Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors

2000 • 22 citations

Calcium on the Up

1999 • 21 citations

Activation of Phospholipases C and D by the Novel Metabotropic Glutamate Receptor Agonist tADA

1997 • 21 citations

Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes

2000 • 21 citations

Extracellular Ca2+ sensitivity of mGluR1alpha associated with persistent glutamate response in transfected CHO cells.

2000 • 21 citations

Functional regulation of metabotropic glutamate receptor type 1c: a role for phosphorylation in the desensitization of the receptor

1999 • 19 citations

Metabotropic glutamate receptor subtype 1a activates adenylate cyclase when expressed in baby hamster kidney cells

1996 • 18 citations

Enhanced Type 1α Metabotropic Glutamate Receptor-Stimulated Phosphoinositide Signaling after Pertussis Toxin Treatment

1997 • 17 citations

Autoradiographic visualization of group III metabotropic glutamate receptors using [³H]‐<scp>L</scp>‐2‐amino‐4‐phosphonobutyrate

1998 • 17 citations

Immunocytochemical localization of metabotropic glutamate receptor type 1α and tubulin in rat brain

2001 • 17 citations

Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor

1999 • 16 citations

Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b

1998 • 14 citations

In vitro translation and membrane topology of rat recombinant mGluR 1α

1994 • 12 citations

Homology model of the closed, functionally active, form of the amino terminal domain of mGluR1

2001 • 9 citations

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

1998 • 9 citations

Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS

1996 • 9 citations

The metabotropic glutamate receptor (MGR): Pharmacology and subcellular location

1992 • 7 citations

Palmitoylation of metabotropic glutamate receptor subtype 4 but not 1α expressed in permanently transfected BHK cells

1995 • 6 citations

Molecular characterization and localization of human metabotropic glutamate receptor type 3

1996 • 6 citations

Different Levels of Receptor Expression as a New Procedure to Estimate Agonist Affinity Constant

1997 • 6 citations

Direct radiolabeling by [3H]quisqualic acid of group I metabotropic glutamate receptor in rat brain synaptic membranes

2000 • 3 citations