Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

CREB AND MEMORY

1998 • 1,421 citations

A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons

1997 • 1,338 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

A new cellular mechanism for coupling inputs arriving at different cortical layers

1999 • 1,171 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1997 • 724 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Toward a molecular definition of long-term memory storage

1996 • 685 citations

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

1998 • 640 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Synergistic Release of Ca2+ from IP3-Sensitive Stores Evoked by Synaptic Activation of mGluRs Paired with Backpropagating Action Potentials

1999 • 334 citations

Nimodipine Facilitates Associative Learning in Aging Rabbits

1989 • 305 citations

Action Potential-Dependent Regulation of Gene Expression: Temporal Specificity in Ca²⁺, cAMP-Responsive Element Binding Proteins, and Mitogen-Activated Protein Kinase Signaling

1997 • 304 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

1999 • 278 citations

Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones.

1995 • 229 citations

Different Ca2+ channels in soma and dendrites of hippocampal pyramidal neurons mediate spike-induced Ca2+ influx

1995 • 222 citations

Regulation of CBP-Mediated Transcription by Neuronal Calcium Signaling

1999 • 220 citations

NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes

1992 • 183 citations

Nuclear calcium signalling by individual cytoplasmic calcium puffs

1997 • 181 citations

Calcium Controls Gene Expression via Three Distinct Pathways That Can Function Independently of the Ras/Mitogen-Activated Protein Kinases (ERKs) Signaling Cascade

1997 • 156 citations

Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.

1993 • 125 citations

Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates.

1984 • 120 citations

Transcription‐dependent neuronal plasticity

2000 • 110 citations

MAPK regulation of gene expression in the central nervous system

2000 • 107 citations

Calcium as a versatile second messenger in the control of gene expression

1999 • 86 citations

Aging and cognition: Facilitation of recent memory in aged nonhuman primates by nimodipine

1990 • 77 citations

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation

1999 • 74 citations

Facilitated nuclear transport of calmodulin in tissue culture cells.

1994 • 66 citations

Old age and cognition: Enhancement of recent memory in aged rats by the calcium channel blocker nimodipine

1992 • 61 citations

Nimodipine in the Treatment of Probable Alzheimerʼs Disease

1996 • 59 citations

Activation of Nuclear Calcium Dynamics by Synaptic Stimulation in Cultured Cortical Neurons

1999 • 37 citations

Spatial Considerations for Stimulus-Dependent Transcription in Neurons

2000 • 28 citations