Structural and functional aspects of G protein-coupled receptor oligomerization

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Dopamine receptor pharmacology

1994 • 959 citations

A Transmembrane Helix Dimer: Structure and Implications

1997 • 949 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer

1996 • 512 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Sequence specificity in the dimerization of transmembrane .alpha.-helixes

1992 • 490 citations

Dimerization of the δ Opioid Receptor:

1997 • 479 citations

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

1992 • 472 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.

1993 • 321 citations

A dimerization motif for transmembrane α–helices

1994 • 313 citations

Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

1996 • 266 citations

The Complete DNA Sequence of Myxoma Virus

1999 • 256 citations

Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling

1996 • 213 citations

β-Adrenergic receptors: Evidence for negative cooperativity

1975 • 200 citations

Bacterial Chemotaxis and the Molecular Logic of Intracellular Signal Transduction Networks

1991 • 193 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor

1994 • 176 citations

Conversion of a gonadotropin-releasing hormone antagonist to an agonist

1982 • 174 citations

Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors

1995 • 172 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Synthetic Peptides Mimic the Assembly of Transmembrane Glycoproteins

1989 • 155 citations

Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide.

1996 • 152 citations

Human serotonin1B receptor expression in Sf9 cells: Phosphorylation, palmitoylation, and adenylyl cyclase inhibition

1993 • 146 citations

No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone

1995 • 146 citations

Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.

1994 • 141 citations

Aspartate receptors of Escherichia coli and Salmonella typhimurium bind ligand with negative and half-of-the-sites cooperativity

1994 • 135 citations

Structural basis of G protein-coupled receptor function

1999 • 119 citations

Palmitoylated Cysteine 341 Modulates Phosphorylation of the β2-Adrenergic Receptor by the cAMP-dependent Protein Kinase

1996 • 116 citations

Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

1985 • 113 citations

Phosphorylation and Palmitoylation of the Human D2_L Dopamine Receptor in Sf9 Cells

1994 • 111 citations

Epidermal Growth Factor

2006 • 110 citations

Gonadotropin-Releasing Hormone

1975 • 105 citations

Allosteric behavior in transducin activation mediated by rhodopsin. Initial rate analysis of guanine nucleotide exchange.

1987 • 105 citations

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

1994 • 102 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

Muscarinic cholinergic receptor structure. Receptor size, membrane orientation, and absence of major phylogenetic structural diversity.

1983 • 101 citations

Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states.

1983 • 100 citations

Functional Role of the Third Cytoplasmic Loop in Muscarinic Receptor Dimerization

1996 • 98 citations

Physical properties of the purified cardiac muscarinic acetylcholine receptor

1986 • 93 citations

Cardiac Muscarinic Receptors. Cooperativity as the Basis for Multiple States of Affinity

1997 • 92 citations

Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation

1997 • 90 citations

Functional rescue of a constitutively desensitized β2AR through receptor dimerization

1998 • 90 citations

The size of the mammalian lung β2-adrenergic receptor as determined by target size analysis and immunoaffinity chromatography

1982 • 88 citations

Intrasubunit Signal Transduction by the Aspartate Chemoreceptor

1991 • 82 citations

The hepatic glucagon receptor. Solubilization, characterization, and development of an affinity adsorption assay for the soluble receptor.

1984 • 82 citations

C-terminal Truncation of the Neurokinin-2 Receptor Causes Enhanced and Sustained Agonist-induced Signaling

1995 • 76 citations

Evidence of paired M2 muscarinic receptors.

1991 • 72 citations

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo

1995 • 68 citations

Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.

1995 • 68 citations

Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.

1997 • 67 citations

The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography

1992 • 65 citations

Receptor aggregation induced by antilutropin receptor antibody and biological response in rat testis Leydig cells.

1983 • 59 citations

Cooperative binding of the retinal rod G-protein, transducin, to light-activated rhodopsin.

1993 • 57 citations

Luteinizing hormone release from dissociated pituitary cells by dimerization of occupied LHRH receptors

1982 • 56 citations

Structure of the turkey erythrocyte adenylate cyclase system.

1981 • 54 citations

A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells

1994 • 49 citations

Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

1994 • 47 citations

Oligomerization of the cytoplasmic fragment from the aspartate receptor of Escherichia coli

1992 • 42 citations

Overexpression, Solubization and Purification of Rat and Human Olfactory Receptors

1996 • 40 citations

Alpha 1-adrenergic receptor structure.

1984 • 40 citations

Radiation Inactivation (Target Size Analysis) of the Gonadotropin-Releasing Hormone Receptor: Evidence for a High Molecular Weight Complex*

1985 • 38 citations

Molecular size of the canine and human brain D2 dopamine receptor as determined by radiation inactivation.

1983 • 38 citations

Dopamine D4 receptors: curiouser and curiouser

1994 • 35 citations

Multisite interactions of receptors and G proteins: enhanced potency of dimeric receptor peptides in modifying G protein function.

1994 • 34 citations

Cardiac Muscarinic Receptors. Relationship between the G Protein and Multiple States of Affinity

1997 • 33 citations

Characterization of the Rat m3 Muscarinic Acetylcholine Receptor Produced in Insect Cells Infected with Recombinant Baculovirus

1995 • 31 citations

Simulations on dimeric peptides: evidence for domain swapping in G-protein-coupled receptors?

1997 • 30 citations

Molecular size of the human platelet alpha2-adrenergic receptor as determined by radiation inactivation

1983 • 29 citations

G protein-linked receptors labeled by [3H]histamine in guinea pig cerebral cortex. II. Mechanistic basis for multiple states of affinity [corrected].

1993 • 26 citations

Target size of the adenosine Ri receptor

1986 • 25 citations

Gonadotropin releasing hormone activation is mediated by dimerization of occupied receptors

1985 • 23 citations

Molecular size characterization of oxytocin receptors in rabbit amnion.

1992 • 19 citations

Solubilization and Characterization of D₂‐Dopamine Receptors in an Estrone‐Induced, Prolactin‐Secreting Rat Pituitary Adenoma

1986 • 18 citations

Luteinizing Hormone Triggers Two Opposite Regulatory Pathways through an Initial Common Event, Receptor Aggregation

1986 • 17 citations

Functional Wild-Type and Carboxy-Terminal-Tagged Rat Substance P Receptors Expressed in Baculovirus-Infected Insect Sf9 Cells

1995 • 16 citations

G protein-linked receptors labeled by [3H]histamine in guinea pig cerebral cortex. I. Pharmacological characterization [corrected].

1993 • 16 citations

Determination of the molecular size of the hepatic H1-receptor by target size analysis

1986 • 14 citations

Ligand-induced receptor dimerization may be critical for signal transduction by choriogonadotropin

1997 • 12 citations