Functional Importance of the Ala116–Pro136 Region in the Calcium-sensing Receptor

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1999 • 724 citations

Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity

1994 • 713 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

A Familial Syndrome of Hypocalcemia with Hypercalciuria Due to Mutations in the Calcium-Sensing Receptor

1996 • 603 citations

Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation

1994 • 589 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1982 • 549 citations

Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes

1996 • 537 citations

Expression and Characterization of Inactivating and Activating Mutations in the Human Ca2+-sensing Receptor

1996 • 430 citations

Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

1995 • 376 citations

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

1999 • 324 citations

Physiology and pathophysiology of the extracellular calcium-sensing receptor

1999 • 269 citations

Short-Term Inhibition of Parathyroid Hormone Secretion by a Calcium-Receptor Agonist in Patients with Primary Hyperparathyroidism

1998 • 248 citations

A Prospectus for Multispectral-Multiplex DNA Sequencing

1989 • 233 citations

Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding

1999 • 209 citations

Mutations in the Ca(2+)-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism

1996 • 205 citations

The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain

1999 • 183 citations

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.

1999 • 180 citations

A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

1996 • 178 citations

Treatment of Hypercalcemia Secondary to Parathyroid Carcinoma with a Novel Calcimimetic Agent

1998 • 177 citations

New perspectives for the development of selective metabotropic glutamate receptor ligands

1999 • 150 citations

Expression and Purification of the Extracellular Ligand Binding Region of Metabotropic Glutamate Receptor Subtype 1

1998 • 147 citations

Functional expression and properties of the human skeletal muscle sodium channel

1994 • 126 citations

Cloned and Expressed Rat Ca2+-sensing Receptor

1996 • 126 citations

The Second Intracellular Loop of the m5 Muscarinic Receptor Is the Switch Which Enables G-protein Coupling

1998 • 125 citations

Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568.

1998 • 123 citations

Pharmacology of muscarinic acetylcholine receptor subtypes (m1–m5): high throughput assays in mammalian cells

1996 • 115 citations

Dimerization of the Calcium-sensing Receptor Occurs within the Extracellular Domain and Is Eliminated by Cys → Ser Mutations at Cys101 and Cys236

1999 • 115 citations

Domains determining ligand specificity for Ca2+ receptors.

1999 • 115 citations

A Carboxyl-terminal Domain Controls the Cooperativity for Extracellular Ca2+ Activation of the Human Calcium Sensing Receptor

1998 • 108 citations

The N-Terminal Domain of γ-Aminobutyric Acid_BReceptors Is Sufficient to Specify Agonist and Antagonist Binding

1999 • 107 citations

Molecular aspects of pheromonal communication via the vomeronasal organ of mammals

1998 • 106 citations

Thrombin Receptor Activating Mutations

1996 • 102 citations

Mutational analysis of the cysteines in the extracellular domain of the human Ca²⁺ receptor: effects on cell surface expression, dimerization and signal transduction

1998 • 97 citations

Sporadic Hypoparathyroidism Caused byde NovoGain- of-Function Mutations of the Ca²⁺-Sensing Receptor¹

1997 • 97 citations

GABAB receptors make it to the top – as dimers

1999 • 92 citations

Identification of a Ligand-dependent Switch within a Muscarinic Receptor

1998 • 88 citations

Structure-Function of Muscarinic Receptor Coupling to G Proteins

1995 • 80 citations

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

1999 • 75 citations

Familial Hypoparathyroidism: Identification of a Novel Gain of Function Mutation in Transmembrane Domain 5 of the Calcium-Sensing Receptor¹

1998 • 74 citations

A Novel Activating Mutation in Calcium-Sensing Receptor Gene Associated with a Family of Autosomal Dominant Hypocalcemia¹

1999 • 68 citations

Two Novel Missense Mutations in Calcium-Sensing Receptor Gene Associated with Neonatal Severe Hyperparathyroidism¹

1997 • 67 citations

An adult patient with severe hypercalcaemia and hypocalciuria due to a novel homozygous inactivating mutation of calcium‐sensing receptor

1999 • 66 citations

Structure of a G-protein-coupling Domain of a Muscarinic Receptor Predicted by Random Saturation Mutagenesis

1996 • 66 citations

Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis.

1995 • 64 citations

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca²⁺ receptor

1999 • 61 citations

Constitutive Activation of the m5 Muscarinic Receptor by a Series of Mutations at the Extracellular End of Transmembrane 6

1997 • 56 citations

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

1999 • 28 citations

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

1999 • 27 citations

A novel mutation (L174R) in the Ca2+-sensing receptor gene associated with familial hypocalciuric hypercalcemia

1997 • 14 citations