Cytoplasmic signalling by the c‐Abl tyrosine kinase in normal and cancer cells

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Complex networks orchestrate epithelial–mesenchymal transitions

2006 • 3,818 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

2007 • 2,249 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Tyrosine Kinases as Targets for Cancer Therapy

2005 • 1,365 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

2004 • 1,249 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

TGFβ–SMAD signal transduction: molecular specificity and functional flexibility

2007 • 1,199 citations

Eph receptor signalling casts a wide net on cell behaviour

2005 • 978 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

A quantitative protein interaction network for the ErbB receptors using protein microarrays

2005 • 718 citations

Structure and regulation of Src family kinases

2004 • 662 citations

The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants

2006 • 645 citations

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

2005 • 636 citations

Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

2004 • 587 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions

2006 • 528 citations

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

2004 • 524 citations

Regulation of the c-Abl and Bcr–Abl tyrosine kinases

2004 • 467 citations

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

2003 • 463 citations

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

2004 • 463 citations

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

2001 • 455 citations

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

2005 • 452 citations

The interplay between Src family kinases and receptor tyrosine kinases

2004 • 446 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro

2007 • 397 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

Identification of Candidate Molecular Markers Predicting Sensitivity in Solid Tumors to Dasatinib: Rationale for Patient Selection

2007 • 338 citations

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR–ABL tyrosine kinase

2001 • 332 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

2003 • 311 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

2005 • 306 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

Regulation of Macropinocytosis by p21-activated Kinase-1

2000 • 293 citations

The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway

2006 • 286 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from β-Catenin

2006 • 269 citations

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

2003 • 260 citations

Protein complexes regulating Arp2/3-mediated actin assembly

2005 • 260 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Autoinhibition of c-Abl

2002 • 244 citations

The mouse c-abl locus: Molecular cloning and characterization

1984 • 223 citations

Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

2005 • 218 citations

Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

2003 • 216 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

A Dynamin–Cortactin–Arp2/3 Complex Mediates Actin Reorganization in Growth Factor-stimulated Cells

2003 • 211 citations

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

2006 • 210 citations

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

2000 • 208 citations

A Novel Endocytic Mechanism of Epidermal Growth Factor Receptor Sequestration and Internalization

2006 • 206 citations

Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

2006 • 196 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion

2002 • 184 citations

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

2002 • 182 citations

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

2002 • 165 citations

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

1995 • 145 citations

Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells.

1993 • 145 citations

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src

1997 • 144 citations

Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes

2001 • 140 citations

Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation

2003 • 140 citations

Regulation of c-myc expression by PDGF through Rho GTPases

2001 • 137 citations

A Critical Role for Cortactin Phosphorylation by Abl-Family Kinases in PDGF-Induced Dorsal-Wave Formation

2007 • 128 citations

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

2004 • 128 citations

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

2003 • 127 citations

Abl tyrosine kinases are required for infection by Shigella flexneri

2003 • 126 citations

Cytoskeletal Protein PSTPIP1 Directs the PEST-Type Protein Tyrosine Phosphatase to the c-Abl Kinase to Mediate Abl Dephosphorylation

2000 • 125 citations

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

2002 • 121 citations

Requirement for Abl Kinases in T Cell Receptor Signaling

2004 • 117 citations

Inhibition of c-Abl Tyrosine Kinase Activity by Filamentous Actin

2001 • 115 citations

Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival

2007 • 109 citations

Endocytosis and cancer

2004 • 106 citations

Activation of cyclin D1 expression by the ERK5 cascade

2003 • 104 citations

Abl Tyrosine Kinase Regulates Endocytosis of the Epidermal Growth Factor Receptor

2006 • 101 citations

Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton

2005 • 91 citations

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase

2001 • 90 citations

c-Abl-mediated Phosphorylation of WAVE3 Is Required for Lamellipodia Formation and Cell Migration

2007 • 86 citations

Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

2007 • 85 citations

c-Abl Interacts with the WAVE2 Signaling Complex to Induce Membrane Ruffling and Cell Spreading

2006 • 85 citations

The Selective Tyrosine Kinase Inhibitor, STI571, Inhibits Growth of Anaplastic Thyroid Cancer Cells

2003 • 84 citations

The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains

2003 • 82 citations

cAbl Tyrosine Kinase Mediates Reactive Oxygen Species– and Caveolin-Dependent AT ₁ Receptor Signaling in Vascular Smooth Muscle

2005 • 81 citations

Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor

2004 • 79 citations

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

1999 • 77 citations

Rac is required for v-Abl tyrosine kinase to activate mitogenesis

1996 • 74 citations

Transforming Growth Factor β Activation of c-Abl Is Independent of Receptor Internalization and Regulated by Phosphatidylinositol 3-Kinase and PAK2 in Mesenchymal Cultures

2006 • 73 citations

Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa

1999 • 71 citations

The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells

2007 • 62 citations

Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles

2006 • 50 citations

Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors

2005 • 48 citations

Cytoplasmic c-Abl provides a molecular ‘Rheostat’ controlling carcinoma cell survival and invasion

2003 • 48 citations

Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene

2006 • 44 citations

Wnt/β-Catenin Signaling Mediates Antineoplastic Effects of Imatinib Mesylate (Gleevec) in Anaplastic Thyroid Cancer

2006 • 39 citations

c-Abl Interacts with the WAVE2 Signaling Complex to Induce Membrane Ruffling and Cell Spreading

2006 • 38 citations

Abl‐kinase‐sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival

2004 • 37 citations

Rhee, J. et al. Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion. Nat. Cell Biol. 4, 798-805

2002 • 36 citations

Abi-1 forms an epidermal growth factor-inducible complex with Cbl: Role in receptor endocytosis

2007 • 26 citations

Abl Tyrosine Kinase Promotes Dorsal Ruffles but Restrains Lamellipodia Extension during Cell Spreading on Fibronectin

2007 • 24 citations

Phosphorylation of c-Abl by Protein Kinase Pak2 Regulates Differential Binding of ABI2 and CRK

2007 • 20 citations

Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells

2004 • 14 citations

Oncogenic cytoplasmic protein tyrosine kinases

1997 • 1 citations