Cytoskeletal Protein PSTPIP1 Directs the PEST-Type Protein Tyrosine Phosphatase to the c-Abl Kinase to Mediate Abl Dephosphorylation

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

1991 • 348 citations

An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias.

1993 • 317 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

1999 • 284 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis

1995 • 254 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

SH3 Domains: Minding your p's and q's

1995 • 197 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

1997 • 176 citations

BCR/ABL induces multiple abnormalities of cytoskeletal function.

1997 • 174 citations

PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase

1997 • 169 citations

Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

1997 • 156 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.

1995 • 148 citations

Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein

1998 • 137 citations

Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST

1999 • 136 citations

Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl

1998 • 123 citations

A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization

1990 • 112 citations

Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo

1998 • 107 citations

Combination of Gene Targeting and Substrate Trapping to Identify Substrates of Protein Tyrosine Phosphatases Using PTP-PEST as a Model

1998 • 105 citations

A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion

1998 • 103 citations

Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling

1999 • 102 citations

Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.

1993 • 87 citations

Intact LIM 3 and LIM 4 Domains of Paxillin Are Required for the Association to a Novel Polyproline Region (Pro 2) of Protein-Tyrosine Phosphatase-PEST

1999 • 85 citations

PSTPIP 2, a Second Tyrosine Phosphorylated, Cytoskeletal-associated Protein That Binds a PEST-type Protein-tyrosine Phosphatase

1998 • 79 citations

The Noncatalytic Domain of Protein-tyrosine Phosphatase-PEST Targets Paxillin for Dephosphorylation in Vivo

2000 • 71 citations

Identification of a Binding Site in c-Abl Tyrosine Kinase for the C-Terminal Repeated Domain of RNA Polymerase II

1996 • 65 citations

c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

1999 • 58 citations

The Protein Kinase Family

1987 • 50 citations

c-ABL Tyrosine Kinase Activity Is Regulated by Association with a Novel SH3-Domain-Binding Protein

1996 • 41 citations

A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells

1996 • 37 citations

Identification of a Novel Polyproline Recognition Site in the Cytoskeletal Associated Protein, Proline Serine Threonine Phosphatase Interacting Protein

1998 • 29 citations

Characterization of the PEST family protein tyrosine phosphatase BDP1.

1996 • 23 citations