A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C

2000 • 986 citations

Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion

2000 • 651 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Signal transduction underlying growth cone guidance by diffusible factors

1999 • 457 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

2000 • 378 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Autoinhibition of c-Abl

2002 • 244 citations

Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C

2000 • 222 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

1993 • 211 citations

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma 1 and Ras activation

1999 • 192 citations

Syndecan-4 Proteoglycan Cytoplasmic Domain and Phosphatidylinositol 4,5-Bisphosphate Coordinately Regulate Protein Kinase C Activity

1998 • 183 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

1992 • 146 citations

Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes

2001 • 140 citations

Pleiotropic Contributions of Phospholipase C-γ1 (PLC-γ1) to T-Cell Antigen Receptor-Mediated Signaling: Reconstitution Studies of a PLC-γ1-Deficient Jurkat T-Cell Line

2000 • 127 citations

Cytoskeletal Protein PSTPIP1 Directs the PEST-Type Protein Tyrosine Phosphatase to the c-Abl Kinase to Mediate Abl Dephosphorylation

2000 • 125 citations

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

2002 • 121 citations

Phosphatidylinositol 4,5-Bisphosphate Induces Actin Stress-Fiber Formation and Inhibits Membrane Ruffling in Cv1 Cells

2001 • 118 citations

Inhibition of c-Abl Tyrosine Kinase Activity by Filamentous Actin

2001 • 115 citations

The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin

2001 • 110 citations

INP51, a Yeast Inositol Polyphosphate 5-Phosphatase Required for Phosphatidylinositol 4,5-Bisphosphate Homeostasis and Whose Absence Confers a Cold-resistant Phenotype

1998 • 101 citations

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

1994 • 97 citations

The c-Abl Tyrosine Kinase Is Regulated Downstream of the B Cell Antigen Receptor and Interacts with CD19

2000 • 76 citations

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor

2001 • 71 citations

Epidermal growth factor induces rapid and transient association of phospholipase c-γ1 with egf-receptor and filamentous actin at membrane ruffles of a431 cells

1995 • 69 citations

Epidermal Growth Factor Signaling and Mitogenesis inPlcg1Null Mouse Embryonic Fibroblasts

1998 • 69 citations

Mediation of chemoattractant-induced changes in [Ca2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils.

1994 • 64 citations

Phosphoinositides as Key Regulators of Synaptic Function

2001 • 63 citations

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

2001 • 60 citations

Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis

1998 • 57 citations

The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation

1997 • 56 citations

Oncogenic Activation of c-ABL by Mutation within Its Last Exon

1993 • 51 citations

Axon guidance: A balance of signals sets axons on the right track

1999 • 49 citations

Overactivation of Phospholipase C-γ1 Renders Platelet-derived Growth Factor β-Receptor-expressing Cells Independent of the Phosphatidylinositol 3-Kinase Pathway for Chemotaxis

1999 • 44 citations

Oncogenic activation of c-ABL by mutation within its last exon.

1993 • 38 citations

Phosphorylation of Phospholipase Cγ1 on Tyrosine Residue 783 by Platelet-Derived Growth Factor Regulates Reorganization of the Cytoskeleton

1998 • 36 citations

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1904 • 7 citations

EXOGENOUS PHOSPHOLIPASE C STIMULATES EPITHELIAL CELL MIGRATION AND INTEGRIN EXPRESSION IN VITRO

2001 • 5 citations