The Selective Tyrosine Kinase Inhibitor, STI571, Inhibits Growth of Anaplastic Thyroid Cancer Cells

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor

2001 • 2,038 citations

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

1993 • 652 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland

1992 • 350 citations

Cycling, stressed-out and nervous: cellular functions of c-Abl

1999 • 324 citations

Anaplastic Thyroid Carcinoma: Behavior, Biology, and Therapeutic Approaches

1998 • 272 citations

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

2000 • 271 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

STI571: Targeting BCR-ABL as Therapy for CML

2001 • 216 citations

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

2000 • 199 citations

Determination of cell fate by c-Abl activation in the response to DNA damage

1998 • 170 citations

The Thyroid A Fundamental and Clinical Text

1957 • 113 citations

All-Trans-Retinoic Acid Modulates Expression Levels of Thyroglobulin and Cytokines in a New Human Poorly Differentiated Papillary Thyroid Carcinoma Cell Line, KTC-1¹

2000 • 109 citations

BCR-ABL and Interleukin 3 Promote Haematopoietic Cell Proliferation and Survival through Modulation of Cyclin D2 and p27Kip1 Expression

2001 • 104 citations

c-Jun N-terminal Kinase Is Essential for Growth of Human T98G Glioblastoma Cells

2000 • 104 citations

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase

2001 • 90 citations

All-Trans-Retinoic Acid Modulates Expression Levels of Thyroglobulin and Cytokines in a New Human Poorly Differentiated Papillary Thyroid Carcinoma Cell Line, KTC-1

2000 • 74 citations

Interleukin-1 Production and Action in Thyroid Tissue

1989 • 67 citations

PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells

2001 • 64 citations

p53 expression in K562 cells is associated with caspase‐mediated cleavage of c‐ABL and BCR–ABL protein kinases

2002 • 36 citations

Bax expression in benign and malignant thyroid tumours: Dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma

2001 • 35 citations

c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency

2000 • 30 citations

The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin

2000 • 26 citations

Induction of expression of MHC-class-II antigen on human thyroid carcinoma by wild-type p53

1998 • 16 citations

c-Abl expression in oral squamous cell carcinomas

2000 • 11 citations

Researchers Buoyed by Promise of Targeted Leukemia Therapy

2000 • 6 citations

Induction of expression of MHC‐class‐II antigen on human thyroid carcinoma by wild‐type p53

1998 • 3 citations