Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Randomized Phase II Trial of the Efficacy and Safety of Trastuzumab Combined With Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Administered As First-Line Treatment: The M77001 Study Group

2005 • 1,570 citations

Rho GTPases and cell migration

2001 • 1,170 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

ErbB Receptors: Directing Key Signaling Networks Throughout Life

2004 • 599 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Imatinib mesylate (STI-571 Glivec®, Gleevec™) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target

2003 • 399 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Src family kinases and HER2 interactions in human breast cancer cell growth and survival

2001 • 187 citations

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

2002 • 165 citations

Mechanisms of platelet-derived growth factor-induced chemotaxis

2001 • 158 citations

Imatinib mesylate lacks activity in small cell lung carcinoma expressing c‐kit protein

2005 • 154 citations

Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes

2001 • 140 citations

Abelson kinase regulates epithelial morphogenesis in Drosophila

2001 • 140 citations

Growth Factor-Induced Cell Motility in Tumor Invasion

2002 • 138 citations

Exploiting the hallmarks of cancer

2003 • 137 citations

Urokinase Plasminogen Activator/Urokinase-specific Surface Receptor Expression and Matrix Invasion by Breast Cancer Cells Requires Constitutive p38α Mitogen-activated Protein Kinase Activity

2000 • 133 citations

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

2004 • 128 citations

Tyrosine kinase signalling in breast cancer

2000 • 128 citations

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

2003 • 127 citations

Abl tyrosine kinases are required for infection by Shigella flexneri

2003 • 126 citations

A role for phospholipase C-gamma-mediated signaling in tumor cell invasion.

1999 • 119 citations

Phospholipase C-gamma1 in tumor progression.

2003 • 117 citations

Acquired resistance to EGFR inhibitors: mechanisms and prevention strategies

2004 • 104 citations

A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer

2005 • 93 citations

Tyrosine kinase inhibitors

2004 • 89 citations

Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor

2004 • 79 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 77 citations

Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro

2003 • 77 citations

Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo

2000 • 75 citations

Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor

2001 • 71 citations

Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa

1999 • 71 citations

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

2001 • 60 citations

Quantitative cell dispersion analysis: New test to measure tumor cell aggressiveness

2001 • 57 citations

Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype.

2002 • 56 citations

Cytoplasmic c-Abl provides a molecular ‘Rheostat’ controlling carcinoma cell survival and invasion

2003 • 48 citations

Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors

2004 • 41 citations

Genomic approaches in the management and treatment of breast cancer

2005 • 40 citations

Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1

1999 • 37 citations

Functional interaction between the epidermal growth factor receptor and c‐Src kinase activity

1994 • 35 citations

STI571 as a potent inhibitor of growth and invasiveness of human epithelial breast cancer cells.

2004 • 32 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 22 citations

ABL oncogene amplification with p16^INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case

2004 • 17 citations

Abl expression, tumour grade, and apoptosis in chondrosarcoma

1999 • 15 citations

Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells

2004 • 14 citations