Abl Tyrosine Kinase Regulates Endocytosis of the Epidermal Growth Factor Receptor

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

2003 • 794 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

A quantitative protein interaction network for the ErbB receptors using protein microarrays

2005 • 718 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain

2006 • 526 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

2004 • 382 citations

The Cbl interactome and its functions

2005 • 380 citations

Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.

2000 • 345 citations

Negative receptor signalling

2003 • 333 citations

Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor and c-Src interactions in breast cancer

2000 • 315 citations

Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits

2003 • 306 citations

Regulation of signal transduction by endocytosis

2000 • 299 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

2002 • 280 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

2002 • 231 citations

Escape from Cbl-mediated downregulation

2003 • 229 citations

Expression profiling of microdissected pancreatic adenocarcinomas

2002 • 226 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

2003 • 201 citations

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

2001 • 200 citations

Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

2006 • 196 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

2004 • 176 citations

Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway

1996 • 175 citations

Mechanisms controlling EGF receptor endocytosis and degradation

2003 • 169 citations

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

2002 • 168 citations

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

1986 • 167 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

2003 • 163 citations

Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors

2003 • 136 citations

Growth Factor Receptor Binding Protein 2-mediated Recruitment of the RING Domain of Cbl to the Epidermal Growth Factor Receptor Is Essential and Sufficient to Support Receptor Endocytosis

2005 • 132 citations

Expression of constitutively activated EGFRvlll in non‐small cell lung cancer

2003 • 129 citations

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

2004 • 128 citations

Abl tyrosine kinases are required for infection by Shigella flexneri

2003 • 126 citations

Endocytosis and cancer

2004 • 106 citations

Epidermal Growth Factor Receptor Activation under Oxidative Stress Fails to Promote c-Cbl Mediated Down-regulation

2002 • 106 citations

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

1996 • 97 citations

HPV16 E5 protein disrupts the c-Cbl–EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes

2005 • 89 citations

Neurons fight back

2005 • 87 citations

Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor

2004 • 79 citations

RENAL MEDULLARY CARCINOMA AND ABL GENE AMPLIFICATION

2005 • 78 citations

The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.

1995 • 76 citations

Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa

1999 • 71 citations

A single amino acid substitution in v-erbB confers a thermolabile phenotype to ts167 avian erythroblastosis virus-transformed erythroid cells.

1986 • 43 citations

Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

1993 • 36 citations