Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

1993 • 211 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

1997 • 167 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine

1998 • 113 citations

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

1997 • 111 citations

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

1998 • 107 citations

Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors

1997 • 99 citations

Regulatory Effect of Phorbol Esters on Sphingosine Kinase in BALB/C 3T3 Fibroblasts (Variant A31): Demonstration of Cell Type-Specific Response - A Preliminary Note

1994 • 87 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

1994 • 80 citations

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

1996 • 78 citations

Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis

1998 • 57 citations

Platelet-derived Growth Factor-dependent Cellular Transformation Requires Either Phospholipase Cγ or Phosphatidylinositol 3 Kinase

1997 • 57 citations

Evidence for separate effects of U73122 on phospholipase C and calcium channels in human platelets

1998 • 44 citations

The Platelet-derived Growth Factor β Receptor Triggers Multiple Cytoplasmic Signaling Cascades That Arrive at the Nucleus as Distinguishable Inputs

1997 • 34 citations

U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells

1998 • 31 citations

Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1

1996 • 30 citations

Non-capacitative Calcium Entry in Chinese Hamster Ovary Cells Expressing the Platelet-derived Growth Factor Receptor

1997 • 12 citations