Abi-1 forms an epidermal growth factor-inducible complex with Cbl: Role in receptor endocytosis

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

2005 • 852 citations

Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae

2002 • 715 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference

2004 • 454 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation

2004 • 393 citations

The Cbl interactome and its functions

2005 • 380 citations

EPS8 and E3B1 transduce signals from Ras to Rac

1999 • 329 citations

Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits

2003 • 306 citations

Regulation of actin dynamics by WASP and WAVE family proteins

2004 • 284 citations

Endocytosis Conducts the Cell Signaling Orchestra

2006 • 274 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

1995 • 251 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

2003 • 214 citations

Syndapins integrate N-WASP in receptor-mediated endocytosis

2002 • 213 citations

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

2001 • 200 citations

Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

2006 • 196 citations

CIN85/CMS family of adaptor molecules

2002 • 196 citations

RING Finger Mutations that Abolish c-Cbl-Directed Polyubiquitination and Downregulation of the EGF Receptor Are Insufficient for Cell Transformation

2001 • 180 citations

Endocytosis and the cytoskeleton

2002 • 179 citations

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits

2005 • 172 citations

Mechanisms controlling EGF receptor endocytosis and degradation

2003 • 169 citations

The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia

2001 • 146 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae

2004 • 143 citations

Abi2-Deficient Mice Exhibit Defective Cell Migration, Aberrant Dendritic Spine Morphogenesis, and Deficits in Learning and Memory

2004 • 129 citations

Abl tyrosine kinases are required for infection by Shigella flexneri

2003 • 126 citations

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

1998 • 117 citations

Role for the Abi/Wave Protein Complex in T Cell Receptor-Mediated Proliferation and Cytoskeletal Remodeling

2006 • 109 citations

Abl Tyrosine Kinase Regulates Endocytosis of the Epidermal Growth Factor Receptor

2006 • 101 citations

Epidermal growth factor pathway substrate 15, Eps15

1999 • 98 citations

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

1996 • 97 citations

A common phosphotyrosine signature for the Bcr-Abl kinase

2006 • 92 citations

Abl Interactor 1 (Abi-1) Wave-Binding and SNARE Domains Regulate Its Nucleocytoplasmic Shuttling, Lamellipodium Localization, and Wave-1 Levels

2004 • 85 citations

Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor

2004 • 79 citations

Regulatory Mechanisms of Dynamin-Dependent Endocytosis

2005 • 68 citations

Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System

2000 • 66 citations

Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases

2000 • 65 citations

Cbl promotes clustering of endocytic adaptor proteins

2005 • 64 citations

The Tyrosine Kinase c-Abl Protects c-Jun from Ubiquitination-mediated Degradation in T Cells

2006 • 49 citations

Endophilin and Synaptojanin Hook Up to Promote Synaptic Vesicle Endocytosis

2003 • 41 citations

The interaction between EEN and Abi-1, two MLLfusion partners, and synaptojanin and dynamin: implications for leukaemogenesis

2000 • 38 citations

Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells

2000 • 26 citations

The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination

2005 • 16 citations