Cytoplasmic c-Abl provides a molecular ‘Rheostat’ controlling carcinoma cell survival and invasion

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

2001 • 455 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

1999 • 420 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

1998 • 363 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

Matrix Survival Signaling

2000 • 360 citations

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR–ABL tyrosine kinase

2001 • 332 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

1998 • 307 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

Extracellular-Regulated Kinase Activation and Cas/Crk Coupling Regulate Cell Migration and Suppress Apoptosis during Invasion of the Extracellular Matrix

2000 • 275 citations

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

1995 • 273 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Autoinhibition of c-Abl

2002 • 244 citations

Extranuclear Apoptosis

1999 • 233 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

1997 • 170 citations

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

2002 • 165 citations

Activation of the Cytoplasmic c-Abl Tyrosine Kinase by Reactive Oxygen Species

2000 • 158 citations

The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL Oncogene

1996 • 143 citations

Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes

2001 • 140 citations

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

2000 • 134 citations

Targeting of the c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced Apoptosis

2001 • 129 citations

Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl

1998 • 123 citations

Inhibition of c-Abl Tyrosine Kinase Activity by Filamentous Actin

2001 • 115 citations

Evidence for a Conserved Role for CrkII and Rac in Engulfment of Apoptotic Cells

2001 • 79 citations

Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases

2000 • 65 citations

Phosphorylation of CrkII Adaptor Protein at Tyrosine 221 by Epidermal Growth Factor Receptor

1998 • 60 citations

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

2001 • 60 citations

ABL mechanisms of regulation and activation

2002 • 54 citations

Crk family adaptor proteins trans‐activate c‐Abl kinase

2001 • 54 citations

Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis

2000 • 51 citations

CRK Protein Binds to Two Guanine Nucleotide-Releasing Proteins for the Ras Family and Modulates Nerve Growth Factor-Induced Activation of Ras in PC12 Cells

1994 • 50 citations

Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin

2002 • 36 citations

Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins. Evidence from reactivity to monoclonal antibodies.

1993 • 33 citations