Aurora-A: the maker and breaker of spindle poles

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

2003 • 3,597 citations

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

2005 • 903 citations

Identification of essential genes in cultured mammalian cells using small interfering RNAs

2001 • 835 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

2005 • 665 citations

The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

2007 • 664 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

2001 • 592 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

2003 • 587 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells.

1990 • 488 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

The Mitotic Spindle: A Self-Made Machine

2001 • 447 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity

1998 • 408 citations

Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

1999 • 379 citations

Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

2001 • 374 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

Analysis of a RanGTP-regulated gradient in mitotic somatic cells

2006 • 370 citations

Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

2000 • 363 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

2004 • 345 citations

The Sudden Recruitment of γ-Tubulin to the Centrosome at the Onset of Mitosis and Its Dynamic Exchange Throughout the Cell Cycle, Do Not Require Microtubules

1999 • 339 citations

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

2004 • 334 citations

Importin Beta

2004 • 332 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly

2001 • 318 citations

Chromosomal passengers: the four-dimensional regulation of mitotic events

2004 • 310 citations

Spindle Assembly in Animal Cells

2000 • 281 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Validating Aurora B as an anti-cancer drug target

2006 • 279 citations

Myosin II-Dependent Cortical Movement Is Required for Centrosome Separation and Positioning during Mitotic Spindle Assembly

2004 • 275 citations

Mitotic mechanics: the auroras come into view

2003 • 269 citations

Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

2005 • 268 citations

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour

2001 • 267 citations

The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells

2003 • 266 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

2004 • 265 citations

N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alphaCaMKII mRNA polyadenylation at synapses

2002 • 258 citations

Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis

2002 • 257 citations

Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

2006 • 257 citations

HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

2006 • 256 citations

Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation

2006 • 254 citations

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

2005 • 252 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Proteome Analysis of the Human Mitotic Spindle

2004 • 244 citations

HURP Is Part of a Ran-Dependent Complex Involved in Spindle Formation

2006 • 244 citations

The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly

1998 • 240 citations

Identification and Characterization of Factors Required for Microtubule Growth and Nucleation in the Early C. elegans Embryo

2005 • 240 citations

Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex

2000 • 238 citations

The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

2005 • 234 citations

The GIT-Associated Kinase PAK Targets to the Centrosome and Regulates Aurora-A

2005 • 229 citations

The Centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila

1999 • 227 citations

Centrosome duplication: of rules and licenses

2007 • 226 citations

Structure and duplication of the centrosome

2007 • 224 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Reconstitution of Physiological Microtubule Dynamics Using Purified Components

2001 • 210 citations

Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

2002 • 208 citations

Centrosome maturation: Measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1

2004 • 204 citations

D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo

2000 • 202 citations

Cooperative mechanisms of mitotic spindle formation

2007 • 192 citations

Re-staging mitosis: a contemporary view of mitotic progression

2001 • 189 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

TOGp, the Human Homolog of XMAP215/Dis1, Is Required for Centrosome Integrity, Spindle Pole Organization, and Bipolar Spindle Assembly

2004 • 186 citations

A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos

1998 • 184 citations

The Control of Cyclin B1 mRNA Translation during Mouse Oocyte Maturation

2000 • 179 citations

Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

2005 • 163 citations

Mitotic Activation of the Kinase Aurora-A Requires Its Binding Partner Bora

2006 • 161 citations

Differential Functions of the Aurora-B and Aurora-C Kinases in Mammalian Spermatogenesis

2006 • 160 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis

2006 • 145 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2004 • 144 citations

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

2000 • 143 citations

hTPX2 Is Required for Normal Spindle Morphology and Centrosome Integrity during Vertebrate Cell Division

2002 • 142 citations

A Functional Interplay Between Aurora-A, Plk1 and TPX2 at Spindle Poles: Plk1 Controls Centrosomal Localization of Aurora-A and TPX2 Spindle Association

2006 • 142 citations

TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos

2003 • 141 citations

NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment

2006 • 141 citations

The centrosomal protein Lats2 is a phosphorylation target of Aurora‐A kinase

2004 • 138 citations

Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

1998 • 135 citations

Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis

2005 • 134 citations

A Microtubule-Independent Role for Centrosomes and Aurora A in Nuclear Envelope Breakdown

2007 • 133 citations

The PITSLRE/CDK11^p58 protein kinase promotes centrosome maturation and bipolar spindle formation

2006 • 129 citations

CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage

2005 • 123 citations

Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3

2004 • 122 citations

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity

2007 • 119 citations

TAC-1, a Regulator of Microtubule Length in the C. elegans Embryo

2003 • 118 citations

Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells

2003 • 118 citations

Aurora A Kinase-Coated Beads Function as Microtubule-Organizing Centers and Enhance RanGTP-Induced Spindle Assembly

2005 • 117 citations

Aurora A, mitotic entry, and spindle bipolarity

2006 • 115 citations

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration

2005 • 112 citations

The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster

1993 • 112 citations

Caenorhabditis elegans TAC-1 and ZYG-9 Form a Complex that Is Essential for Long Astral and Spindle Microtubules

2003 • 110 citations

Degradation of human Aurora‐A protein kinase is mediated by hCdh1

2002 • 104 citations

Two Phases of Astral Microtubule Activity during Cytokinesis in C. elegans Embryos

2006 • 97 citations

LATS2–Ajuba complex regulates γ‐tubulin recruitment to centrosomes and spindle organization during mitosis

2006 • 95 citations

Centrosomes Promote Timely Mitotic Entry in C. elegans Embryos

2007 • 90 citations

Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13.3–ter

1998 • 89 citations

Dynamic association of a tumor amplified kinase, Aurora‐A, with the centrosome and mitotic spindle

2003 • 88 citations

Ran at a glance

2006 • 75 citations

Centrosomal TACCtics

2002 • 70 citations

Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes

2003 • 60 citations

The relationship of HsEg5 and the actin cytoskeleton to centrosome separation

1996 • 54 citations

Mechanisms of Spindle-Pole Organization Are Influenced by Kinetochore Activity in Mammalian Cells

2007 • 49 citations

Involvement of Aurora A Kinase during Meiosis I-II Transition inXenopus Oocytes

2003 • 48 citations

Distribution of microtubules during centriole separation in rat kangaroo (Potorous) cells.

1976 • 44 citations

Centrosomes and Kinetochores, Who Needs 'Em? The Role of Noncentromeric Chromatin in Spindle Assembly

2003 • 10 citations