The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells.

1990 • 488 citations

γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

1992 • 447 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Centrosome organization and centriole architecture: Their sensitivity to divalent cations

1992 • 365 citations

A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

1992 • 356 citations

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

1987 • 346 citations

Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells.

1990 • 312 citations

The Chromosome Cycle and the Centrosome Cycle in the Mitotic Cycle

1987 • 263 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

The effects of Colcemid inhibition and reversal on the fine structure of the mitotic apparatus of Chinese hamster cells in vitro

1967 • 212 citations

Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules.

1987 • 199 citations

ULTRASTRUCTURAL ANALYSIS OF MITOTIC SPINDLE ELONGATION IN MAMMALIAN CELLS IN VITRO

1971 • 184 citations

Astral microtubules are not required for anaphase B in Saccharomyces cerevisiae.

1992 • 171 citations

Mechanics of chromosome separation during mitosis in Fusarium (Fungi imperfecti): new evidence from ultrastructural and laser microbeam experiments.

1981 • 169 citations

Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibers.

1991 • 149 citations

Functional autonomy of monopolar spindle and evidence for oscillatory movement in mitosis.

1982 • 145 citations

Interzone microtubule behavior in late anaphase and telophase spindles.

1987 • 134 citations

Light and electron microscopy of Rat kangaroo cells in mitosis

1973 • 121 citations

A monoclonal antibody to a mitotic microtubule-associated protein blocks mitotic progression.

1990 • 107 citations

Experimental separation of pronuclei in fertilized sea urchin eggs: chromosomes do not organize a spindle in the absence of centrosomes.

1985 • 100 citations

Astral and spindle forces in PtK2 cells during anaphase B: a laser microbeam study

1993 • 99 citations

Newt Lung Epithelial Cells: Cultivation, Use, and Advantages for Biomedical Research

1990 • 88 citations

Mitotic motors.

1991 • 85 citations

Direct experimental evidence for the existence, structural basis and function of astral forces during anaphase B in vivo

1991 • 78 citations

Dynamics of Spindle Formation and Its Inhibition by Chemicals

1959 • 73 citations

Mitosis: basic concepts

1989 • 69 citations

Formation of the astral mitotic spindle: Ultrastructural basis for the centrosome-kinetochore interaction

1990 • 63 citations

The absence of centrioles from spindle poles of rat kangaroo (PtK2) cells undergoing meiotic-like reduction division in vitro.

1977 • 63 citations

Spindle Fiber Action and Chromosome Movement

1991 • 62 citations

Functional redundancy in mitotic force generation.

1993 • 60 citations

Asters, Poles, and Transport Properties within Spindlelike Microtubule Arrays

1982 • 60 citations

Centriole behavior in early mitosis of rat kangaroo cells (PTK2)

1976 • 58 citations

Variations in the distribution and migration of centriole duplexes in mitotic ptk2 cells studied by immunofluorescence microscopy

1980 • 50 citations

Micromanipulation studies of the mitotic apparatus in sand dollar eggs

1988 • 44 citations

Interzonal microtubules are dynamic during spindle elongation

1990 • 36 citations

Antiparallel microtubule interactions: Spindle formation and anaphase B

1990 • 33 citations

In situ analysis of normal and abnormal patterns of the mitotic apparatus in cultured rat-kangaroo cells

1970 • 30 citations

The mechanism of anaphase spindle elongation

1989 • 29 citations

Inhibition of spindle elongation by taxol

1991 • 26 citations

Sucrose-induced spindle elongation in mitotic PtK-1 cells.

1984 • 14 citations

Reactivation of isolated mitotic apparatus: Metaphase versus anaphase spindles

1991 • 10 citations

Anaphase motions in dilute colchicine. Evidence of two phases in chromosome segregation.

1973 • 9 citations